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CRYSTAL STRUCTURE OF ESCHERICHIA COLI URACIL DNA GLYCOSYLASE AND ITS COMPLEXES WITH URACIL AND GLYCEROL: STRUCTURE AND GLYCOSYLASE MECHANISM REVISITED

Source organism: Escherichia coli B
Biochemical function: hydrolase activity, hydrolyzing N-glycosyl compounds
Biological process: base-excision repair, AP site formation via deaminated base removal
Cellular component: cytoplasm

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EC 3.2.2.27: Uracil-DNA glycosylase

Reaction catalysed:
Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil
Systematic name:
Uracil-DNA deoxyribohydrolase (uracil-releasing)
Alternative Name(s):
  • UDG
  • UdgB
  • Uracil DNA glycohydrolase
  • Uracil-DNA N-glycosylase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF03167
Domain description: Uracil DNA glycosylase superfamily
Occurring in:
  1. Uracil-DNA glycosylase
The deposited structure of PDB entry 3eug contains 1 copy of Pfam domain PF03167 (Uracil DNA glycosylase superfamily) in Uracil-DNA glycosylase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002043
Domain description: Uracil-DNA glycosylase family 1
Occurring in:
  1. Uracil-DNA glycosylase
IPR005122
Domain description: Uracil-DNA glycosylase-like
Occurring in:
  1. Uracil-DNA glycosylase
IPR036895
Domain description: Uracil-DNA glycosylase-like domain superfamily
Occurring in:
  1. Uracil-DNA glycosylase
IPR018085
Domain description: Uracil-DNA glycosylase, active site
Occurring in:
  1. Uracil-DNA glycosylase

Structure domain

CATH CATH domain
3.40.470.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Uracil-DNA Glycosylase, subunit E
Homology: Uracil-DNA glycosylase-like domain
Occurring in:
  1. Uracil-DNA glycosylase
The deposited structure of PDB entry 3eug contains 1 copy of CATH domain 3.40.470.10 (Uracil-DNA Glycosylase, subunit E) in Uracil-DNA glycosylase. Showing 1 copy in chain A.
SCOP SCOP annotation
52142
Class: Alpha and beta proteins (a/b)
Fold: Uracil-DNA glycosylase-like
Superfamily: Uracil-DNA glycosylase-like
Occurring in:
  1. Uracil-DNA glycosylase
The deposited structure of PDB entry 3eug contains 1 copy of SCOP domain 52142 (Uracil-DNA glycosylase) in Uracil-DNA glycosylase. Showing 1 copy in chain A.

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