› › Function and Biology

Calcium-saturated GCaMP2 T116V/K378W mutant monomer

Source organisms:
Biochemical function: calcium ion binding
Biological process: bioluminescence
Cellular component: not assigned

Quick links

EC 2.7.11.18: Myosin-light-chain kinase

Reaction catalysed:
ATP + [myosin light-chain] = ADP + [myosin light-chain] phosphate
Systematic name:
ATP:[myosin-light-chain] O-phosphotransferase
Alternative Name(s):
  • ATP:myosin-light-chain O-phosphotransferase
  • Calcium/calmodulin-dependent myosin light chain kinase
  • MLCK
  • MLCkase
  • Myosin kinase
  • Myosin light chain kinase
  • Myosin light chain protein kinase
  • Myosin light-chain kinase
  • Myosin light-chain kinase (phosphorylating)
  • STK18
  • Smooth-muscle-myosin-light-chain kinase
  • [Myosin-light-chain] kinase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF13499
Domain description: EF-hand domain pair
Occurring in:
  1. Calmodulin-1; Green fluorescent protein; Myosin light chain kinase, smooth muscle, deglutamylated form
The deposited structure of PDB entry 3ekh contains 2 copies of Pfam domain PF13499 (EF-hand domain pair) in Calmodulin-1. Showing 2 copies in chain A.

PF01353
Domain description: Green fluorescent protein
Occurring in:
  1. Calmodulin-1; Green fluorescent protein; Myosin light chain kinase, smooth muscle, deglutamylated form
The deposited structure of PDB entry 3ekh contains 1 copy of Pfam domain PF01353 (Green fluorescent protein) in Calmodulin-1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002048
Domain description: EF-hand domain
Occurring in:
  1. Calmodulin-1; Green fluorescent protein; Myosin light chain kinase, smooth muscle, deglutamylated form
IPR000786
Domain description: Green fluorescent protein, GFP
Occurring in:
  1. Calmodulin-1; Green fluorescent protein; Myosin light chain kinase, smooth muscle, deglutamylated form
IPR018247
Domain description: EF-Hand 1, calcium-binding site
Occurring in:
  1. Calmodulin-1; Green fluorescent protein; Myosin light chain kinase, smooth muscle, deglutamylated form
IPR009017
Domain description: Green fluorescent protein
Occurring in:
  1. Calmodulin-1; Green fluorescent protein; Myosin light chain kinase, smooth muscle, deglutamylated form
IPR011992
Domain description: EF-hand domain pair
Occurring in:
  1. Calmodulin-1; Green fluorescent protein; Myosin light chain kinase, smooth muscle, deglutamylated form
IPR011584
Domain description: Green fluorescent protein-related
Occurring in:
  1. Calmodulin-1; Green fluorescent protein; Myosin light chain kinase, smooth muscle, deglutamylated form

Structure domains

CATH CATH domains
1.10.238.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Recoverin; domain 1
Homology: EF-hand
Occurring in:
  1. Calmodulin-1; Green fluorescent protein; Myosin light chain kinase, smooth muscle, deglutamylated form
The deposited structure of PDB entry 3ekh contains 1 copy of CATH domain 1.10.238.10 (Recoverin; domain 1) in Calmodulin-1. Showing 1 copy in chain A.
2.40.155.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Green Fluorescent Protein
Homology: Green fluorescent protein
Occurring in:
  1. Calmodulin-1; Green fluorescent protein; Myosin light chain kinase, smooth muscle, deglutamylated form
The deposited structure of PDB entry 3ekh contains 1 copy of CATH domain 2.40.155.10 (Green Fluorescent Protein) in Calmodulin-1. Showing 1 copy in chain A.

Quick links