Function and Biology

Beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ) from Plasmodium falciparum in complex with NAS91-11

Source organism: Plasmodium falciparum
Biochemical function: hydro-lyase activity
Biological process: fatty acid biosynthetic process
Cellular component: not assigned

EC 4.2.1.59: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase

Reaction catalysed:
A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H(2)O
Systematic name:
(3R)-3-hydroxyoctanoyl-[acyl-carrier protein] hydro-lyase (trans-2-enoyl-[acyl-carrier protein]-forming)
Alternative Name(s):
  • (3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] hydro-lyase
  • (3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] hydro-lyase (oct-2-enoyl-[acyl-carrier protein]-forming)
  • 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase
  • Beta-hydroxyoctanoyl thioester dehydratase
  • Beta-hydroxyoctanoyl-ACP-dehydrase
  • Beta-hydroxyoctanoyl-acyl carrier protein dehydrase
  • D-3-hydroxyoctanoyl-[acyl carrier protein] dehydratase
  • FabA (gene name)
  • FabZ (gene name)

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF07977
Domain description: FabA-like domain
Occurring in:
  1. 3-hydroxyacyl-[acyl-carrier-protein] dehydratase
The deposited structure of PDB entry 3azb contains 24 copies of Pfam domain PF07977 (FabA-like domain) in 3-hydroxyacyl-[acyl-carrier-protein] dehydratase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR010084
Domain description: Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ
Occurring in:
  1. 3-hydroxyacyl-[acyl-carrier-protein] dehydratase
IPR013114
Domain description: Beta-hydroxydecanoyl thiol ester dehydrase, FabA/FabZ
Occurring in:
  1. 3-hydroxyacyl-[acyl-carrier-protein] dehydratase
IPR029069
Domain description: HotDog domain superfamily
Occurring in:
  1. 3-hydroxyacyl-[acyl-carrier-protein] dehydratase

Structure domain

CATH CATH domain
3.10.129.10
Class: Alpha Beta
Architecture: Roll
Topology: Thiol Ester Dehydrase; Chain A
Homology: Hotdog Thioesterase
Occurring in:
  1. 3-hydroxyacyl-[acyl-carrier-protein] dehydratase
The deposited structure of PDB entry 3azb contains 24 copies of CATH domain 3.10.129.10 (Thiol Ester Dehydrase; Chain A) in 3-hydroxyacyl-[acyl-carrier-protein] dehydratase. Showing 1 copy in chain A.