X-ray diffraction
1.95Å resolution

Structural insights into the catalytic mechanism of CD38: Evidence for a conformationally flexible covalent enzyme-substrate complex

Source organism: Bos taurus
Entry authors: Egea PF, Muller-Stauffler H, Kohn I, Cakou-Kefir C, Stroud RM, Kellenberburger E, Schuber F

Function and Biology Details

Reactions catalysed:
(1a) NAD(+) = cyclic ADP-ribose + nicotinamide
(1a) NADP(+) = 2'-phospho-cyclic ADP-ribose + nicotinamide
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 278 amino acids
Theoretical weight: 31.59 KDa
Source organism: Bos taurus
Expression system: Komagataella pastoris
  • Canonical: Q9TTF5 (Residues: 1-278; Coverage: 100%)
Gene name: CD38
Sequence domains: ADP-ribosyl cyclase
Structure domains:

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P212121
Unit cell:
a: 46.205Å b: 80.029Å c: 157.725Å
α: 90° β: 90° γ: 90°
R R work R free
0.209 0.205 0.252
Expression system: Komagataella pastoris