X-ray diffraction
1.43Å resolution

Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases: SPOPMATHx-MacroH2ASBCpep2


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Speckle-type POZ protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 145 amino acids
Theoretical weight: 16.49 KDa
Source organism: Pongo abelii
Expression system: Escherichia coli
  • Canonical: Q5NVK7 (Residues: 28-166; Coverage: 37%)
Gene name: SPOP
Sequence domains: MATH domain
Structure domains: Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A
Core histone macro-H2A.1 Chain: M
Molecule details ›
Chain: M
Length: 16 amino acids
Theoretical weight: 1.54 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: O75367 (Residues: 172-186; Coverage: 4%)
Gene names: H2AFY, MACROH2A1

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: C2
Unit cell:
a: 88.953Å b: 43.086Å c: 87.453Å
α: 90° β: 118.15° γ: 90°
R R work R free
0.175 0.174 0.206
Expression systems:
  • Escherichia coli
  • Not provided