PDBe 2qe4

X-ray diffraction
2.4Å resolution

Estrogen receptor alpha ligand-binding domain in complex with a benzopyran agonist


Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Estrogen receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 248 amino acids
Theoretical weight: 28.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P03372 (Residues: 304-551; Coverage: 42%)
Gene names: ESR, ESR1, NR3A1
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: C2
Unit cell:
a: 103.915Å b: 54.091Å c: 84.169Å
α: 90° β: 91.24° γ: 90°
R R work R free
0.241 0.241 0.279
Expression system: Escherichia coli BL21(DE3)