› 2mqw

Solution NMR

Solution structure of a proteasome related subunit N terminal domain

Released:
DOI: 10.2210/pdb2mqw/pdb
PDB entry 2mqw coloured by chain, ensemble of 20 models, front view.
PDB entry 2mqw coloured by chain, ensemble of 20 models, side view.
PDB entry 2mqw coloured by chain, ensemble of 20 models, top view.
Source organism: Saccharomyces cerevisiae S288C
Primary publication:
Solution structure of yeast Rpn9: insights into proteasome lid assembly.
Hu Y, Wu Y, Li Q, Zhang W, Jin C
J Biol Chem 290 6878-89 (2015)
PMID: 25631053

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169991 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
26S proteasome regulatory subunit RPN9 Chain: A
Molecule details ›
Chain: A
Length: 163 amino acids
Theoretical weight: 19.21 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Escherichia coli
UniProt:
  • Canonical: Q04062 (Residues: 1-160; Coverage: 41%)
Gene names: D9461.14, NAS7, RPN9, YDR427W
Sequence domains: PSD13 N-terminal repeats

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 86%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Precise assembly and regulation of 26S proteasome and correlation between proteasome dysfunction and neurodegenerative diseases.
Im et al. (2016)
3 more

3 mentions without citation

Atomic structure of the 26S proteasome lid reveals the mechanism of deubiquitinase inhibition.
Dambacher et al. (2016)
2 more