› 2m4x

Solution NMR

Analysis of the structural and molecular basis of voltage-sensitive sodium channel inhibition by the spider toxin, Huwentoxin-IV (-TRTX-Hh2a).

Released:
DOI: 10.2210/pdb2m4x/pdb
PDB entry 2m4x coloured by chain, ensemble of 20 models, front view.
PDB entry 2m4x coloured by chain, ensemble of 20 models, side view.
PDB entry 2m4x coloured by chain, ensemble of 20 models, top view.
Source organism: Cyriopagopus schmidti
Primary publication:
Analysis of the structural and molecular basis of voltage-sensitive sodium channel inhibition by the spider toxin huwentoxin-IV (μ-TRTX-Hh2a).
Minassian NA, Gibbs A, Shih AY, Liu Y, Neff RA, Sutton SW, Mirzadegan T, Connor J, Fellows R, Husovsky M, Nelson S, Hunter MJ, Flinspach M, Wickenden AD
J Biol Chem 288 22707-20 (2013)
PMID: 23760503

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160683 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Huwentoxin-IV Chain: A
Molecule details ›
Chain: A
Length: 35 amino acids
Theoretical weight: 4.12 KDa
Source organism: Cyriopagopus schmidti
Expression system: Homo sapiens
UniProt:
  • Canonical: P83303 (Residues: 53-87; Coverage: 54%)
Sequence domains: Ion channel inhibitory toxin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 41%
Refinement method: simulated annealing
Expression system: Homo sapiens

Quick links

Citations

10 review citations

Recent progress in sodium channel modulators for pain.
Bagal et al. (2014)
9 more

9 mentions without citation

Structure-Function and Therapeutic Potential of Spider Venom-Derived Cysteine Knot Peptides Targeting Sodium Channels.
Cardoso et al. (2019)
8 more