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Lipocalin Q83 reveals a dual ligand binding mode with potential implications for the functions of siderocalins.

Coudevylle N, Hoetzinger M, Geist L, Kontaxis G, Hartl M, Bister K, Konrat R
Biochemistry 50 9192-9 (2011)
Cited: 8 times
EuropePMC logo PMID: 21951132

Abstract

Siderocalins are particular lipocalins that participate in the innate immune response by interfering with bacterial siderophore-mediated iron uptake. Additionally, siderocalins are involved in several physiological and pathological processes such as inflammation, iron delivery, tissue differentiation, and cancer progression. Here we show that siderocalin Q83 displays an unexpected dual ligand binding mode as it can bind enterobactin and unsaturated fatty acids simultaneously. The solution structure of the siderocalin Q83 in complex with arachidonic acid and enterobactin reveals molecular details of this novel dual binding mode and the determinants of fatty acid binding specificity. Our results suggest that Q83 is a metabolic hub linking iron and fatty acid pathways. This unexpected coupling might contribute to the pleiotropic functions of siderocalins.

Articles - 2lbv mentioned but not cited (1)

  1. Protein Structure Idealization: How accurately is it possible to model protein structures with dihedral angles? Cui X, Li SC, Bu D, Alipanahi B, Li M. Algorithms Mol Biol 8 5 (2013)


Reviews citing this publication (2)

  1. Cellular and mitochondrial iron homeostasis in vertebrates. Chen C, Paw BH. Biochim Biophys Acta 1823 1459-1467 (2012)
  2. Siderocalins: Siderophore binding proteins evolved for primary pathogen host defense. Sia AK, Allred BE, Raymond KN. Curr Opin Chem Biol 17 150-157 (2013)

Articles citing this publication (5)

  1. Characterization of chicken spleen transcriptome after infection with Salmonella enterica serovar Enteritidis. Matulova M, Rajova J, Vlasatikova L, Volf J, Stepanova H, Havlickova H, Sisak F, Rychlik I. PLoS One 7 e48101 (2012)
  2. Identification and comparative proteomic study of quail and duck egg white protein using 2-dimensional gel electrophoresis and matrix-assisted laser desorption/ionization time-of-flight tandem mass spectrometry analysis. Hu S, Qiu N, Liu Y, Zhao H, Gao D, Song R, Ma M. Poult Sci 95 1137-1144 (2016)
  3. Avian lipocalin expression in chickens following Escherichia coli infection and inhibition of avian pathogenic Escherichia coli growth by Ex-FABP. Garénaux A, Houle S, Folch B, Dallaire G, Truesdell M, Lépine F, Doucet N, Dozois CM. Vet Immunol Immunopathol 152 156-167 (2013)
  4. Gene Expression Profiles of Chicken Embryo Fibroblasts in Response to Salmonella Enteritidis Infection. Szmolka A, Wiener Z, Matulova ME, Varmuzova K, Rychlik I. PLoS One 10 e0127708 (2015)
  5. Complete NMR chemical shift assignments of odorant binding protein 22 from the yellow fever mosquito, Aedes aegypti, bound to arachidonic acid. Jones DNM, Wang J, Murphy EJ. Biomol NMR Assign 13 187-193 (2019)


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