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Structure and kinetics of a monomeric glucosamine-6-phosphate deaminase: missing link of the NagB superfamily

Source organism: Bacillus subtilis
Biochemical function: identical protein binding
Biological process: N-acetylneuraminate catabolic process
Cellular component: cytoplasm

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EC 3.5.99.6: Glucosamine-6-phosphate deaminase

Reaction catalysed:
Alpha-D-glucosamine 6-phosphate + H(2)O = D-fructose 6-phosphate + NH(3)
Systematic name:
2-amino-2-deoxy-D-glucose-6-phosphate aminohydrolase (ketol isomerizing)
Alternative Name(s):
  • Aminodeoxyglucosephosphate isomerase
  • GlcN6P deaminase
  • Glucosamine phosphate deaminase
  • Glucosamine-6-phosphate isomerase
  • Glucosaminephosphate isomerase
  • Phosphoglucosamine isomerase
  • Phosphoglucosaminisomerase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01182
Domain description: Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
Occurring in:
  1. Glucosamine-6-phosphate deaminase 1
The deposited structure of PDB entry 2bkv contains 2 copies of Pfam domain PF01182 (Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase) in Glucosamine-6-phosphate deaminase 1. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR004547
Domain description: Glucosamine-6-phosphate isomerase
Occurring in:
  1. Glucosamine-6-phosphate deaminase 1
IPR018321
Domain description: Glucosamine-6-phosphate isomerase, conserved site
Occurring in:
  1. Glucosamine-6-phosphate deaminase 1
IPR006148
Domain description: Glucosamine/galactosamine-6-phosphate isomerase
Occurring in:
  1. Glucosamine-6-phosphate deaminase 1
IPR037171
Domain description: NagB/RpiA transferase-like
Occurring in:
  1. Glucosamine-6-phosphate deaminase 1

Structure domain

CATH CATH domain
3.40.50.1360
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. Glucosamine-6-phosphate deaminase 1
The deposited structure of PDB entry 2bkv contains 2 copies of CATH domain 3.40.50.1360 (Rossmann fold) in Glucosamine-6-phosphate deaminase 1. Showing 1 copy in chain B.

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