› 2gib

X-ray diffraction
1.75Å resolution

Crystal structure of the SARS coronavirus nucleocapsid protein dimerization domain

Released:
DOI: 10.2210/pdb2gib/pdb
PDB entry 2gib coloured by chain, front view.
PDB entry 2gib coloured by chain, side view.
PDB entry 2gib coloured by chain, top view.
Source organism: Severe acute respiratory syndrome-related coronavirus
Primary publication:
Crystal structure of the severe acute respiratory syndrome (SARS) coronavirus nucleocapsid protein dimerization domain reveals evolutionary linkage between corona- and arteriviridae.
Yu IM, Oldham ML, Zhang J, Chen J
OpenAccess logo J Biol Chem 281 17134-17139 (2006)
PMID: 16627473

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-157823 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleoprotein Chains: A, B
Molecule details ›
Chains: A, B
Length: 103 amino acids
Theoretical weight: 11.55 KDa
Source organism: Severe acute respiratory syndrome-related coronavirus
Expression system: Escherichia coli
UniProt:
  • Canonical: P59595 (Residues: 270-370; Coverage: 24%)
Gene names: 9a, N

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: C2
Unit cell:
a: 124.163Å b: 50.49Å c: 41.479Å
α: 90° β: 108.92° γ: 90°
R-values:
R R work R free
0.19 0.187 0.235
Expression system: Escherichia coli

Quick links

Citations

15 review citations

The coronavirus nucleocapsid is a multifunctional protein.
McBride et al. (2014)
14 more

22 mentions without citation

From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses.
Hilgenfeld et al. (2013)
21 more