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Three-dimensional NMR structure of the sixth ligand-binding module of the human LDL receptor: comparison of two adjacent modules with different ligand binding specificities.

Clayton D, Brereton IM, Kroon PA, Smith R
FEBS Lett 479 118-22 (2000)
Cited: 9 times
EuropePMC logo PMID: 10981718

Abstract

The sixth ligand-binding module of the low-density lipoprotein receptor contributes to the binding of apolipoprotein B100-containing lipoproteins. 1H NMR spectroscopy, DYANA and X-PLOR structure calculations were used to determine that this module has a well defined structure with a backbone conformation similar to other modules. Structures from calculations that simulated the presence of a calcium ion showed increased resolution without large increases in energy, increased deviations from idealised geometry or violations of experimental constraints. Investigation of the surface properties of this module indicates there are significant differences from the fifth module, which binds apolipoprotein E-containing lipoproteins in addition to apolipoprotein B100-containing lipoproteins.

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Reviews citing this publication (3)

  1. Structure and physiologic function of the low-density lipoprotein receptor. Jeon H, Blacklow SC. Annu Rev Biochem 74 535-562 (2005)
  2. The low-density lipoprotein receptor: ligands, debates and lore. Rudenko G, Deisenhofer J. Curr Opin Struct Biol 13 683-689 (2003)
  3. NMR studies of lipoprotein structure. Cushley RJ, Okon M. Annu Rev Biophys Biomol Struct 31 177-206 (2002)

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  1. Mode of interaction between beta2GPI and lipoprotein receptors suggests mutually exclusive binding of beta2GPI to the receptors and anionic phospholipids. Lee CJ, De Biasio A, Beglova N. Structure 18 366-376 (2010)
  2. Apolipoprotein E-low density lipoprotein receptor binding: study of protein-protein interaction in rationally selected docked complexes. Prévost M, Raussens V. Proteins 55 874-884 (2004)
  3. Structural basis for ligand capture and release by the endocytic receptor ApoER2. Hirai H, Yasui N, Yamashita K, Tabata S, Yamamoto M, Takagi J, Nogi T. EMBO Rep 18 982-999 (2017)


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