› 7jxh

X-ray diffraction
3.27Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138062 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor tyrosine-protein kinase erbB-2 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 326 amino acids
Theoretical weight: 36.88 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P04626 (Residues: 703-1024; Coverage: 26%)
Gene names: ERBB2, HER2, MLN19, NEU, NGL
Sequence domains: Protein tyrosine and serine/threonine kinase

Ligands and Environments

1 bound ligand:
Ligand VOY 8 x VOY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P21
Unit cell:
a: 91.138Å b: 154.617Å c: 93.548Å
α: 90° β: 102.47° γ: 90°
R-values:
R R work R free
0.241 0.239 0.285
Expression system: Spodoptera frugiperda

Quick links

Citations

4 review citations

p53/MicroRNA-34 axis in cancer and beyond.
Pan et al. (2023)
3 more

4 mentions without citation

A Novel HER2-Selective Kinase Inhibitor Is Effective in HER2 Mutant and Amplified Non-Small Cell Lung Cancer.
Son et al. (2022)
3 more