› 6zuz

Solution NMR

TFIIS N-terminal domain (TND) from human Elongin-A

Released:
DOI: 10.2210/pdb6zuz/pdb
PDB entry 6zuz coloured by chain, ensemble of 40 models, front view.
PDB entry 6zuz coloured by chain, ensemble of 40 models, side view.
PDB entry 6zuz coloured by chain, ensemble of 40 models, top view.
Source organism: Homo sapiens
Primary publication:
A ubiquitous disordered protein interaction module orchestrates transcription elongation.
Cermakova K, Demeulemeester J, Lux V, Nedomova M, Goldman SR, Smith EA, Srb P, Hexnerova R, Fabry M, Madlikova M, Horejsi M, De Rijck J, Debyser Z, Adelman K, Hodges HC, Veverka V
Science 374 1113-1121 (2021)
PMID: 34822292

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171977 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Elongin-A Chain: A
Molecule details ›
Chain: A
Length: 90 amino acids
Theoretical weight: 9.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14241 (Residues: 1-82; Coverage: 11%)
Gene names: ELOA, MSTP059, TCEB3
Sequence domains: TFIIS helical bundle-like domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 94%
Refinement method: molecular dynamics
Expression system: Escherichia coli

Quick links

Citations

5 review citations

The molecular basis for cellular function of intrinsically disordered protein regions.
Holehouse et al. (2024)
4 more

2 mentions without citation

The TFIIS N-terminal domain (TND): a transcription assembly module at the interface of order and disorder.
Cermakova et al. (2023)
1 more