› 6h3s

X-ray diffraction
2.02Å resolution

Schmallenberg Virus Glycoprotein Gc Head/Stalk Domains

Released:
DOI: 10.2210/pdb6h3s/pdb
PDB entry 6h3s coloured by chain, front view.
PDB entry 6h3s coloured by chain, side view.
PDB entry 6h3s coloured by chain, top view.
Source organism: Bovine Schmallenberg virus BH80/Germany/2011
Primary publication:
Orthobunyavirus spike architecture and recognition by neutralizing antibodies.
Hellert J, Aebischer A, Wernike K, Haouz A, Brocchi E, Reiche S, Guardado-Calvo P, Beer M, Rey FA
OpenAccess logo Nat Commun 10 879 (2019)
PMID: 30787296

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-124730 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycoprotein C Chains: A, B
Molecule details ›
Chains: A, B
Length: 421 amino acids
Theoretical weight: 47.87 KDa
Source organism: Bovine Schmallenberg virus BH80/Germany/2011
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: H2AM12 (Residues: 465-874; Coverage: 30%)
Gene name: GP
Sequence domains: Bunyavirus glycoprotein G1

Ligands and Environments

3 bound ligands:
Ligand NAG 4 x NAG
Ligand SO4 11 x SO4
Ligand CL 5 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P41212
Unit cell:
a: 95.226Å b: 95.226Å c: 204.739Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.21 0.24
Expression system: Drosophila melanogaster

Quick links

Citations

6 review citations

Orthobunyaviruses: From Virus Binding to Penetration into Mammalian Host Cells.
Windhaber et al. (2021)
5 more

5 mentions without citation

Recent Advances in Bunyavirus Glycoprotein Research: Precursor Processing, Receptor Binding and Structure.
Hulswit et al. (2021)
4 more