› 4xos

X-ray diffraction
1.56Å resolution

ANP32A LRR domain

Released:
DOI: 10.2210/pdb4xos/pdb
PDB entry 4xos coloured by chain, front view.
PDB entry 4xos coloured by chain, side view.
PDB entry 4xos coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
High-resolution crystal structure of the leucine-rich repeat domain of the human tumour suppressor PP32A (ANP32A).
Zamora-Caballero S, Šiaučiunaite-Gaubard L, Bravo J
Acta Crystallogr F Struct Biol Commun 71 684-7 (2015)
PMID: 26057796

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153930 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acidic leucine-rich nuclear phosphoprotein 32 family member A Chains: A, B
Molecule details ›
Chains: A, B
Length: 152 amino acids
Theoretical weight: 17.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P39687 (Residues: 1-149; Coverage: 60%)
Gene names: ANP32A, C15orf1, LANP, MAPM, PHAP1
Sequence domains: Leucine-rich repeat
Structure domains: Ribonuclease Inhibitor

Ligands and Environments

2 bound ligands:
Ligand CL 2 x CL
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALBA BEAMLINE XALOC
Spacegroup: P21
Unit cell:
a: 48.04Å b: 50.88Å c: 63.02Å
α: 90° β: 110.19° γ: 90°
R-values:
R R work R free
0.162 0.16 0.193
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 citations in other articles

Acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) association with lymph node metastasis predicts poor survival in oral squamous cell carcinoma patients.
Velmurugan et al. (2016)

4 mentions without citation

Host ANP32A mediates the assembly of the influenza virus replicase.
Carrique et al. (2020)
3 more