› 4jl9

X-ray diffraction
3.1Å resolution

Crystal structure of mouse TBK1 bound to BX795

Released:
DOI: 10.2210/pdb4jl9/pdb
PDB entry 4jl9 coloured by chain, front view.
PDB entry 4jl9 coloured by chain, side view.
PDB entry 4jl9 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural insights into the functions of TBK1 in innate antimicrobial immunity.
Shu C, Sankaran B, Chaton CT, Herr AB, Mishra A, Peng J, Li P
Structure 21 1137-48 (2013)
PMID: 23746807

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194393 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase TBK1 Chain: A
Molecule details ›
Chain: A
Length: 657 amino acids
Theoretical weight: 75.69 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9WUN2 (Residues: 2-656; Coverage: 90%)
Gene name: Tbk1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand BX7 1 x BX7
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P3221
Unit cell:
a: 140.782Å b: 140.782Å c: 86.57Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.231 0.227 0.269
Expression system: Spodoptera frugiperda

Quick links

Citations

11 review citations

Evolution of Two Major Zika Virus Lineages: Implications for Pathology, Immune Response, and Vaccine Development.
Beaver et al. (2018)
10 more

1 mention without citation

Structural insights into the functions of TBK1 in innate antimicrobial immunity.
Shu et al. (2013)