› 3uia

X-ray diffraction
2Å resolution

Structural Determinants of Trimerization Specificity in HIV-1 gp41 Protein

Released:
DOI: 10.2210/pdb3uia/pdb
PDB entry 3uia coloured by chain, front view.
PDB entry 3uia coloured by chain, side view.
PDB entry 3uia coloured by chain, top view.
Source organism: Human immunodeficiency virus type 1 (Z2/CDC-Z34 ISOLATE)
Entry authors: Liu J, Lu M

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146173 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transmembrane protein gp41 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 53 amino acids
Theoretical weight: 6.18 KDa
Source organism: Human immunodeficiency virus type 1 (Z2/CDC-Z34 ISOLATE)
Expression system: Escherichia coli
UniProt:
  • Canonical: P12487 (Residues: 537-589; Coverage: 6%)
Gene name: env
Structure domains: Single alpha-helices involved in coiled-coils or other helix-helix interfaces

Ligands and Environments

2 bound ligands:
Ligand CL 1 x CL
Ligand MPD 4 x MPD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: C2
Unit cell:
a: 78.027Å b: 76.316Å c: 65.731Å
α: 90° β: 104.86° γ: 90°
R-values:
R R work R free
0.214 0.212 0.252
Expression system: Escherichia coli

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