› 3sxn

X-ray diffraction
2.03Å resolution

Mycobacterium tuberculosis Eis protein initiates modulation of host immune responses by acetylation of DUSP16/MKP-7

Released:
DOI: 10.2210/pdb3sxn/pdb
PDB entry 3sxn coloured by chain, front view.
PDB entry 3sxn coloured by chain, side view.
PDB entry 3sxn coloured by chain, top view.
Source organism: Mycolicibacterium smegmatis MC2 155
Primary publication:
Mycobacterium tuberculosis Eis protein initiates suppression of host immune responses by acetylation of DUSP16/MKP-7.
Kim KH, An DR, Song J, Yoon JY, Kim HS, Yoon HJ, Im HN, Kim J, Kim DJ, Lee SJ, Kim KH, Lee HM, Kim HJ, Jo EK, Lee JY, Suh SW
Proc Natl Acad Sci U S A 109 7729-34 (2012)
PMID: 22547814

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-106372 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
N-acetyltransferase domain-containing protein Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 422 amino acids
Theoretical weight: 46.13 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
Expression system: Escherichia coli
UniProt:
  • Canonical: A0QY29 (Residues: 1-402; Coverage: 100%)
Gene name: MSMEG_3513
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand COA 6 x COA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 4A
Spacegroup: P212121
Unit cell:
a: 107.737Å b: 126.518Å c: 238.8Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.182 0.181 0.217
Expression system: Escherichia coli

Quick links

Citations

56 review citations

Mitogen-activated protein kinases in innate immunity.
Arthur et al. (2013)
55 more

8 mentions without citation

Structure and Functional Diversity of GCN5-Related N-Acetyltransferases (GNAT).
Salah Ud-Din et al. (2016)
7 more