› 2n8f

Solution NMR

Chemical shift assignments and structure calculation of spider toxin pi-hexatoxin-Hi1a

Released:
DOI: 10.2210/pdb2n8f/pdb
PDB entry 2n8f coloured by chain, ensemble of 20 models, front view.
PDB entry 2n8f coloured by chain, ensemble of 20 models, side view.
PDB entry 2n8f coloured by chain, ensemble of 20 models, top view.
Source organism: Hadronyche infensa
Primary publication:
Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a.
Chassagnon IR, McCarthy CA, Chin YK, Pineda SS, Keramidas A, Mobli M, Pham V, De Silva TM, Lynch JW, Widdop RE, Rash LD, King GF
Proc Natl Acad Sci U S A 114 3750-3755 (2017)
PMID: 28320941

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-103521 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pi-hexatoxin-Hi1a Chain: A
Molecule details ›
Chain: A
Length: 76 amino acids
Theoretical weight: 8.75 KDa
Source organism: Hadronyche infensa
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: A0A1L1QJU3 (Residues: 1-75; Coverage: 100%)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 88%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli BL21

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Citations

30 review citations

The Diversity of Venom: The Importance of Behavior and Venom System Morphology in Understanding Its Ecology and Evolution.
Schendel et al. (2019)
29 more

4 mentions without citation

Antibodies and venom peptides: new modalities for ion channels.
Wulff et al. (2019)
3 more