› 1ezt

Solution NMR

HIGH-RESOLUTION SOLUTION STRUCTURE OF FREE RGS4 BY NMR

Released:
DOI: 10.2210/pdb1ezt/pdb
PDB entry 1ezt coloured by chain, front view.
PDB entry 1ezt coloured by chain, side view.
PDB entry 1ezt coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
NMR structure of free RGS4 reveals an induced conformational change upon binding Galpha.
Moy FJ, Chanda PK, Cockett MI, Edris W, Jones PG, Mason K, Semus S, Powers R
Biochemistry 39 7063-73 (2000)
PMID: 10852703

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156048 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Regulator of G-protein signaling 4 Chain: A
Molecule details ›
Chain: A
Length: 166 amino acids
Theoretical weight: 19.15 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P49799 (Residues: 51-205; Coverage: 76%)
Gene name: Rgs4
Sequence domains: Regulator of G protein signaling domain
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry simulated annealing
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Regulators of G-protein signalling as new central nervous system drug targets.
Neubig et al. (2002)
6 more

7 mentions without citation

The RGS protein inhibitor CCG-4986 is a covalent modifier of the RGS4 Galpha-interaction face.
Kimple et al. (2007)
6 more