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{
    "metadata": {
        "accession": "G5ASM7",
        "id": "G5ASM7_HETGA",
        "source_organism": {
            "taxId": "10181",
            "scientificName": "Heterocephalus glaber",
            "fullName": "Heterocephalus glaber (Naked mole rat)"
        },
        "name": "Proenkephalin-A",
        "description": [
            "Increases glutamate release in the striatum and decreases GABA concentration in the striatum",
            "Met-enkephalin-Arg-Phe neuropeptide acts as a strong ligand of Mu-type opioid receptor OPRM1. Met-enkephalin-Arg-Phe-binding to OPRM1 in the nucleus accumbens of the brain increases activation of OPRM1, leading to long-term synaptic depression of glutamate release",
            "Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress"
        ],
        "length": 266,
        "sequence": "MARFLRLCTWLLALGPGVLATVQAECSQDCATCSYRLVRPGGLNFLACTLECEGQLPSLKIWETCRDLLQASKQELPQEGTNLFRESSKQDEGHLLSKKYGGFMKRYGGFMKKMDELYSMEPEEEANGGEILAKRYGGFMKKDAEEGDALANSSDLLKELLGADHERESYHQEGVDNDDDVSKRYGGFMRGLKRSPQLEDEAKELQKRYGGFMRRVGRPEWWMDYQKRYGGFLKRFADSLPSDEEGESYSKEVPEMEKRYGGFMRF",
        "proteome": "UP000694906",
        "gene": "Penk",
        "go_terms": [
            {
                "identifier": "GO:0007218",
                "name": "neuropeptide signaling pathway",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "6fa08cbd40ae6cd5bb2038f6d2313e3785d0712e",
        "counters": {
            "domain_architectures": 2355,
            "entries": 7,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 0,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "panther": 1,
                "pfam": 1,
                "prints": 2,
                "prosite": 1,
                "interpro": 2
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 2355
        }
    }
}