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{
    "metadata": {
        "accession": "A0A7N4V3M7",
        "id": "A0A7N4V3M7_SARHA",
        "source_organism": {
            "taxId": "9305",
            "scientificName": "Sarcophilus harrisii",
            "fullName": "Sarcophilus harrisii (Tasmanian devil)"
        },
        "name": "Trimethylguanosine synthase",
        "description": [
            "Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation"
        ],
        "length": 890,
        "sequence": "MLCGKWSLVAEMVLFIEDLEEDLKILCLCSRAFVEDRKLYYLGLKGFYVKDNDTSNTEQATEEREYNSHGLVESENGSALRSDDIELDSEAELMRSMGLPLQFGGLSAHKNFEVSMNSRNKKTKFKKKKKKSQKKYTDEILQESWKEIHEDDDHLISDDASLAFEQYEETKTCELQNEKEVEDGKLSTENVLPPKLEITEKWQKYWSEYGEGLLWQSWQENHPGEILSTEPWNSPETKEKWEQHYSHIYWYYLEQFQYWEGQGWTFDCSQSCDMDNCMSKIEMDKKDNRNITRGSLLDLVSVTKKSEDIYKENTNDKHHEEILDGISNINLNSVELENDSLNSAVICGDYQCLGEVNSEQRSTLSNECEPCDGSTKKRNLSGNKSASQADSQETSGTSPNKEVSYSNNKDGDESEEEPPEYKPAKLKRSHELDIEENPIMDFDDNGSLLGFQHGSGQKNSIIGDVYFKNLFKKSIQRYGGISNFSRRKVKYIQKDVKHKTQFLDMRRQINAKNKHIFFPEESERSSSRKSKTLSKVEKFLKWVNEPVEGIPSQDPQDDAQETCTSSDSEEQERSVKKYDDPFEISNLEPEKRDVFSSNNEFEMEKNKDDNKITVTEQKCVSERQLVTLDIPDYLQVETDVEAKKKKKKSKKKSKTQNPLPPEIAAVPELAKYWAQRYRLFSRFDDGIKLDKEGWFSVTPEKIAEHIAGRVQLSFNCDIIVDAFCGVGGNAIQFALTGKRVIAIDIDPTKIDLAHNNAEVYGVADKIEFICGDFMLLASDLKADVVFLSPPWGGPDYATAETFDIRTMMSPDGFEIFRLSQMITKNIVYFLPRNADIDQVASLAGPGGQVEIEQNFLNNKLKTITAYFGDLIRRTASEIPVKNDLKEGSIE",
        "proteome": "UP000007648",
        "gene": "TGS1",
        "go_terms": [
            {
                "identifier": "GO:0008168",
                "name": "methyltransferase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0001510",
                "name": "RNA methylation",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0036261",
                "name": "7-methylguanosine cap hypermethylation",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "ida_accession": "ffeebc7aeab4f3e59ad6c6c560bad577f8bebdfd",
        "counters": {
            "domain_architectures": 4264,
            "entries": 7,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 2,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 1,
                "ssf": 1,
                "cdd": 1,
                "panther": 1,
                "pfam": 1,
                "interpro": 2
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 4264
        }
    }
}