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{
    "metadata": {
        "accession": "A0A7J7RVP7",
        "id": "A0A7J7RVP7_PIPKU",
        "source_organism": {
            "taxId": "59472",
            "scientificName": "Pipistrellus kuhlii",
            "fullName": "Pipistrellus kuhlii (Kuhl's pipistrelle)"
        },
        "name": "TNFAIP3-interacting protein 2",
        "description": [
            "Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes"
        ],
        "length": 429,
        "sequence": "MSSGDAGPGGREGAPRAAAALCGLYHEAGQQLRRLQEQLAARDALIERLRARLAALEGDAAPSLVDALLEQVARFREQLRRREGDAGAVEAALRQEIQRLSEQLAAKEAAARQRASPGPEREEELAARQRASPGPEREEELAALRRRVAEKERARAASDTLCRSLADESRQLRRTLAATAHMCQHLARRLEAGQGAAGEQRPEPEHAGGDASVQAAVQKLQEENRLLKQKLTHVEDLNAKWQRYDASRDEYVQELRAQLRTLQAPQAEAEELLRKEIARLNGQLEERLGECAGAARELAAARERAQMLEQQILAYKDDFTSERADRERAQGRIQELEDQVAALQRQARRQGPPEAGSCRIHTASRAPRHAETKASERPVSASRGPAPVEGGGPGAGRRGQGDLQCPHCLQCFRDEQGEELLRHVAECCQ",
        "proteome": "UP000558488",
        "gene": "mPipKuh1_017826",
        "go_terms": [
            {
                "identifier": "GO:0070530",
                "name": "K63-linked polyubiquitin modification-dependent protein binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "protein_evidence": 4,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "ida_accession": "65d0cb2b364b042a177d9624f29b963ea446183f",
        "counters": {
            "domain_architectures": 1531,
            "entries": 6,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 0,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "pfam": 1,
                "cathgene3d": 1,
                "profile": 1,
                "panther": 1,
                "interpro": 2
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 1531
        }
    }
}