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{
    "metadata": {
        "accession": "A0A6J2PCT0",
        "id": "A0A6J2PCT0_COTGO",
        "source_organism": {
            "taxId": "56716",
            "scientificName": "Cottoperca gobio",
            "fullName": "Cottoperca gobio (Frogmouth)"
        },
        "name": "B-cell receptor CD22",
        "description": [
            "Most highly expressed siglec (sialic acid-binding immunoglobulin-like lectin) on B-cells that plays a role in various aspects of B-cell biology including differentiation, antigen presentation, and trafficking to bone marrow. Binds to alpha 2,6-linked sialic acid residues of surface molecules such as CD22 itself, CD45 and IgM in a cis configuration. Can also bind to ligands on other cells as an adhesion molecule in a trans configuration. Acts as an inhibitory coreceptor on the surface of B-cells and inhibits B-cell receptor induced signaling, characterized by inhibition of the calcium mobilization and cellular activation. Mechanistically, the immunoreceptor tyrosine-based inhibitory motif domain is phosphorylated by the Src kinase LYN, which in turn leads to the recruitment of the protein tyrosine phosphatase 1/PTPN6, leading to the negative regulation of BCR signaling. If this negative signaling from is of sufficient strength, apoptosis of the B-cell can be induced"
        ],
        "length": 582,
        "sequence": "MALPAAARGLVVFLLCVTEIQCESDWGVTYTSAEICAAKGSSVDMSCTYRYPTSKDGIQTYSIVTQHFWHLQKNLKDLSELPKYSGHVTYPCSSERENVCCLRITNLTESDSAEYMFRFITNQPGGSWSGVPGVKLTVSALQIQVTRVNQSSTEAELSCHSNCNDPSYVWFKNGQKVPEEASSYTNHFNPGDNISCALKGHEDSGSPSLYAPKLPSVSVSPGEIMKGSSVNLSCSSDANPAANYTWYKINQTLLSEGPQLVFSSIRSSDSGQYHCAAENELRRTTSANIFINVKYGPKLPSVSVSPSAEIEEGSSVTLSCSSDANPAANYTWYKEDGNLKPLSEDPQLVFSSIQSSDSGQYQCRAQNKLGMKESKSISIDVKYGPKLPSVSVSPSAEIEEGSSVTLSCSSDANPAANYTWYKEDEDSPKASGQNFTITDFRSEHSGNYYCEAQNSRGRRDSTLHLTVGAGQGILSAVVTMTAVLIIFILISVALWVRLLTRKEGAPKPSPEPKGGPDVSAQKPPAEQKDTLHYAVVHFSKRQADPINPDTRPALPQIHTSEEKVDSVEYATVKCNGVSTAPG",
        "proteome": "UP000504630",
        "gene": "LOC115005478",
        "go_terms": null,
        "protein_evidence": 4,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "8e28975fc4df9e1b96a6bdadc37044188597f808",
        "counters": {
            "domain_architectures": 70,
            "entries": 15,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 2,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 1,
                "ssf": 1,
                "smart": 2,
                "pfam": 2,
                "profile": 1,
                "cdd": 1,
                "panther": 1,
                "interpro": 6
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 70
        }
    }
}