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{
    "metadata": {
        "accession": "A0A401PEH9",
        "id": "A0A401PEH9_SCYTO",
        "source_organism": {
            "taxId": "75743",
            "scientificName": "Scyliorhinus torazame",
            "fullName": "Scyliorhinus torazame (Cloudy catshark)"
        },
        "name": "Bifunctional apoptosis regulator",
        "description": [
            "Membrane-bound E3 ubiquitin ligase that plays a role in several processes including apoptosis regulation or reticulum endoplasmic stress. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors. Contributes to the dynamic control of IRE1/ERN1 signaling during ER stress by inducing BAX inhibitor 1/TMBIM6 proteasomal degradation. Promotes the activation of TGF-beta signaling by mediating the 'Lys-63'-linked ubiquitination of TGFBR1 which is critical to activate the pathway. Together with NGFR, negatively regulates NF-kappa-B and JNK-related signaling pathways. Promotes the proteasome-mediated degradation of PNPLA3, a protein involveld in lipid metabolism"
        ],
        "length": 452,
        "sequence": "MEADVGFRNRQRYKEQWEELDDSTFPEPSCQLSANEFSCHCCYEILVNPTTLNCGHSFCRHCLALWWDASRKTECPECREKWEGFPKVNIVLRDAVEKLFPDDVTRRQEETRNNIKISNSVLAFQKYGNEQSRPFNNSGHWRRGGGFFSGVLTSLTCVAVVFLVYLWSRETEQDLLVHKPVTKWTAKEVTLWLEQLGQWATVYKDRFLEEEVNGRLLLTLGEEEFSKPPFNIERELHRKAILMELDNVKALGVKPPQNLWEYKAMHVGKSLFLLYALKSSPRLTMLYLYLFDYSELFLPLIHTISPEKIEMTEDADIFRKHWSDDISLKQWAEFLVKYTLIPYQLIAEFAWDWLDMHYWTSRFIIVNAMLLSVLEGFAFWRLWSRGGLRTIPQKMWSHFWKVSSQGILVAILWPIIPQFVCDCLFYWALYFNPIINIDLVVKEVRRLETEMP",
        "proteome": "UP000288216",
        "gene": "scyTo_0008862",
        "go_terms": [
            {
                "identifier": "GO:0046872",
                "name": "metal ion binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0005515",
                "name": "protein binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "protein_evidence": 4,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "1e27e84cadd48c4a1aa23de2331e374351f29605",
        "counters": {
            "domain_architectures": 112,
            "entries": 20,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 4,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 2,
                "ssf": 2,
                "cdd": 2,
                "smart": 2,
                "pfam": 2,
                "profile": 2,
                "panther": 1,
                "prosite": 1,
                "interpro": 6
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 112
        }
    }
}