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{
    "metadata": {
        "accession": "A0A2U3WTZ5",
        "id": "A0A2U3WTZ5_ODORO",
        "source_organism": {
            "taxId": "9708",
            "scientificName": "Odobenus rosmarus divergens",
            "fullName": "Odobenus rosmarus divergens (Pacific walrus)"
        },
        "name": "Sialidase-4",
        "description": [
            "Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Efficiently hydrolyzes gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3. Hydrolyzes poly-alpha-(2->8)-sialylated neural cell adhesion molecule NCAM1 likely at growth cones, suppressing neurite outgrowth in hippocampal neurons. May desialylate sialyl Lewis A and X antigens at the cell surface, down-regulating these glycan epitopes recognized by SELE/E selectin in the initiation of cell adhesion and extravasation. Has sialidase activity toward mucin, fetuin and sialyllactose"
        ],
        "length": 491,
        "sequence": "MEAPRVPERTVLFQRERSGLTYRVPALLPVPPAPTLLAFAEQRLSPDDAHAHRLVQRSGTLAGGSVRWGAAHVLGTAALEEHRSMNPCPVHDARTATIFLFFIAVRGRTPEATQIATGRNAARLCCVTSRDAGRSWDAARDLTEEAVGSAEQDWATFAVGPGHGIQLRSGRLLVPAYAYRVDRRECFGKICRTSPHAFTFYSDDHGRTWHRGGLVPNLRSGECQLAAVDGQQAGSILYCNARSPLGRRVQALSADEGASFLPGELVPALAETARGCQGSILGFPAPLSGRPRGEGWSAGARNHPESPRLCPGVQQPSEEGTADTQGDQGLGRMEGWKDSPEEPGPEPGLSETRDAWAPSLPGPPATLSQSPTWLLYSHPAGRRARLHMGIHLSQSPLDPYSWTEPWVIYEGPSGYSDLASIGPTLKGALTFACLYESGARVSYEEISFCMFSLAEVLQNVPGPAPPSRRGKPRERCRPSRWALWPDPFVCP",
        "proteome": "UP000245340",
        "gene": "NEU4",
        "go_terms": [
            {
                "identifier": "GO:0004308",
                "name": "exo-alpha-sialidase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "02425dadc08b857ad018027199832781349e8f30",
        "counters": {
            "domain_architectures": 15397,
            "entries": 8,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 2,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 1,
                "ssf": 1,
                "cdd": 1,
                "pfam": 1,
                "panther": 1,
                "interpro": 3
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 15397
        }
    }
}