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{
    "metadata": {
        "accession": "A0A2K5CLN8",
        "id": "A0A2K5CLN8_AOTNA",
        "source_organism": {
            "taxId": "37293",
            "scientificName": "Aotus nancymaae",
            "fullName": "Aotus nancymaae (Ma's night monkey)"
        },
        "name": "Calcium-binding and coiled-coil domain-containing protein 1",
        "description": [
            "Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions. In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells",
            "Seems to enhance inorganic pyrophosphatase thus activating phosphogluomutase (PMG). Probably functions as a component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth"
        ],
        "length": 691,
        "sequence": "MEESPLSRVPSRGGVNFLNVARTYIPNTKVECHYTLPPGTMPSASDWIGIFKVEAACVRDYHTFVWSSVPESTTDGSPIHTSVQFQASYLPKPGAQLYQFRYVNRQGRVCGQSPPFQFREPRPMDELVTMEEADGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEAQVTELRSRVQELERVLATAREEHAELTEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLMKEVELDRVRDTVKALTREQEKLLGQLKEVQADKEQSEAELQAAQQENRRLNLELQEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKAILLGEELASAAASRDRTIAELHRSRLEVAEVNSRLAELSLHLKEEKSQWSKEQSGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVLKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDGATEDEEAAAGLSCPAALTDSEDESPEDMRLPPYGPCEHGDPGSSPAGPREASPLVVISQPAPISSHLSGPAEDSSSDSEAEDEKSVLMAAVQSGGEEANLLLPELGSAFYDMASGFTVGPLSEAGTGGPATPTWKECPICKERFPAESDKDALEDHMDRHFFFSTQDPFTFE",
        "proteome": "UP000233020",
        "gene": "CALCOCO1",
        "go_terms": null,
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "aba947fa2933e8c59bea93419d686a7e21ac7f5d",
        "counters": {
            "domain_architectures": 398,
            "entries": 12,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 3,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 2,
                "pfam": 3,
                "profile": 1,
                "cdd": 1,
                "panther": 1,
                "interpro": 4
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 398
        }
    }
}