HTTP 200 OK
Allow: GET, HEAD
Content-Type: application/json
InterPro-Version: 108.0
InterPro-Version-Minor: 0
Vary: Accept
{
"metadata": {
"accession": "K9JHZ4",
"id": "TET3B_XENLA",
"source_organism": {
"taxId": "8355",
"scientificName": "Xenopus laevis",
"fullName": "Xenopus laevis (African clawed frog)"
},
"name": "Methylcytosine dioxygenase tet3-B",
"description": [
"Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development. Conversion of 5mC into 5hmC probably constitutes the first step in cytosine demethylation. Selectively binds to the promoter region of target genes and contributes to regulate the expression of numerous developmental genes, including pax6, rax, sox9 and six3. May also contribute to the regulation of target genes in ways that do not require its enzyme activity"
],
"length": 1915,
"sequence": "METQPASVPCVLPQDVYEFSEDRESLGRLRVSEMPSELNGGGDGSKGDGAAVVATEVSQQSNKKRKRCGVCVPCLRKEPCGTCYNCVNRSTSHQICKMRKCEQLKKKRVVPMKGVEAVDKDDAKNQAKEQVPSVKNCSESILVDGPKTDQMEAGPVNHVQEGRLKQECDSTLPSKGSEDLANQLLMEANSWLSNTAAPQDPCNKLNWDKPIIPNHIAANNNSNLEDAKNLVAFSAVAEAMSNYGMPASGTPSSISMQLYEKFNYETNQDNSGHSEGNAPSCPEDLNTLKEALALAKHGVKPPNCNCDGPECPDYLEWLENKIKSTGKGSQESPFPSLGQVSKKLVQKSYHKEQVLNLENTNVTCPSGNLPFSQNALSLAKEKNISLQTAIAIEALTQLSSALPQTNNEYPNAPSQPLINHNDQLTHFPTAKGNQLPMLPLSCNELFQNQQAQLYTGKNALPVPQSPRQASWEQNKKPGYQESEYIPENLSQSSSVLPSDASTPQKKEFLQQWVQNADLLKSPSDPMTGLKQLLGNTDEYIKSAFKGPEGLSKKIKNVKSKHTIKSIKKESADFTKMSPDQQLSQLLQGNDFHRNTQAALQQHLHHKRNLFVDSNTMEACTQEQQNWWVPNSQQAPVSKTTEKPVKERKKRRQSPSQKQVEPKPKPPRKQVQIKKPRVKEGNAVFMPVSQISLDSFRRVEKEENQVKELDLENSLPINVQPDLLGSQSIQLTGSQANLENQKTVNTQETCNENQTSIGKANNFALCVNKTNSLVAKGRCPTPSTGDSSSGQGDSANQHTNLTDVPGQNDLSCIDDKFEDLIKQFAAEFGEDFSLPGSEVPSQNGERPPKQQTSGVPQFKMPFPSQLPSENATHSNPALSNNLLTHNASHKFDSLFSSKSPKQIKIESSGAITVVSTTCSYSEENQHLDGTPTKSELPFNPTLSGFLESPLKYLTSPTKSLIDTPAKMAQAEFPTCDCVEQINEKDEGPYYTHLGSGPTVASIRELMEERFGEKGEAIRIEKVIYTGKEGKSSRGCPIAKWVIRRQSEDEKLMCLVRQRAGHHCENAVIIILIMAWEGIPRALGDSLYDDISGTITKYGNPTSRRCGLNDDRTCACQGKDPNTCGASFSFGCSWSMYFNGCKYARSKTPRKFRLIGDNPKEEEFLKDSFQDLATKVAPVYKMLAPQAYQNQANNEDVAIDCRLGLEEGRPFSGVTACMDFCAHAHKDQHNLYNGCTVVCTLTKEDNRMIGKIAEDEQLHVLPLYKVSTTDEFGSEERQLEKIRKGGIQVLSSFPREVRKLSEPAKSCRQRQLDAKKATAEKKKLQKEKLVSPDKTKQEPSDTKTCQQNPGVPQQQTKPCVKVEPSNHYNTFKYNGNGVVESYSVLGSCRPSDPYSMNSVYSYHSFYAQPNLPSVNGFHSKFALPPFGFYSFPNNPVVPNQFMNYGTGDARNSGWMNNSFEKKPELQSLADGMNQSYGSELPEQNYRRSSEVPHHYSLQNSNSQKSVGVPHRTTPAPMETTPYSNVPCYNKVIKKEPVCDPLVDPFQRSNSVHSQSPGVNHSLQTNDLSYKANGALPSSGRTNKEGPCSMFLPSDKNGLEKRDYFGVHSNVPGLKEKQWTPYGIDVPVGQRDSLDSQCSGKVWSSCKLSDSPAVMPSTVQDKNWTGRQASLNQGVKEPMPFQEKLWNSVAASGRCSTTPNDRSSVTPCAELQDKNWMSFPNPAVNSLKTDSSQNHWDPYSLDDNMDDGQSKSVKEEEDEEEIWSDSEHNFLDGNIGGVAVAPGHGSILIECARRELHATTPLKKPNRCHPTRISLVFYQHKNLNQPNHGLALWEAKMKQLAERARVKEEEAAKLGIKQEVKSLGKKRKWGGAATTETPPVEKKDFIPTRQAATSLTDSTTTAFSYAYTKVTGPYSRFI",
"proteome": "UP000186698",
"gene": "tet3-b",
"go_terms": [
{
"identifier": "GO:0003677",
"name": "DNA binding",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0008270",
"name": "zinc ion binding",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0016706",
"name": "2-oxoglutarate-dependent dioxygenase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0040029",
"name": "epigenetic regulation of gene expression",
"category": {
"code": "P",
"name": "biological_process"
}
}
],
"protein_evidence": 1,
"source_database": "reviewed",
"is_fragment": false,
"in_alphafold": true,
"in_bfvd": false,
"ida_accession": "50b365ed69c333a1b58e2ca1e13a59ded66afc42",
"counters": {
"domain_architectures": 645,
"entries": 10,
"isoforms": 0,
"proteomes": 1,
"sets": 2,
"structures": 0,
"taxa": 1,
"dbEntries": {
"pfam": 2,
"profile": 1,
"cdd": 1,
"smart": 1,
"panther": 1,
"interpro": 4
},
"proteome": 1,
"taxonomy": 1,
"similar_proteins": 645
}
}
}
