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{
    "metadata": {
        "accession": "W2RRU3",
        "id": "W2RRU3_CYPE1",
        "source_organism": {
            "taxId": "1220924",
            "scientificName": "Cyphellophora europaea (strain CBS 101466)",
            "fullName": "Cyphellophora europaea (strain CBS 101466)"
        },
        "name": "2-(3-amino-3-carboxypropyl)histidine synthase subunit 2",
        "description": [
            "Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit"
        ],
        "length": 547,
        "sequence": "MAEGLSAPPVLSTPDTHILNDASDAHLESEHLSDEQLETRYEIARTLKEIKQHRWQRLALQFPDDMLPHSTRVYRLLARGLDSKSHPPPASPEPVPEAEGSVNGDISKLALDEDVKLTILGDTSYGSCCVDEIAAEHVNADAVIHYGRSCLSPTARLPVVHVFTDRPIDRHRAIEAFKSAFPDPSSKVVVTADVPYASHVSALSQQLIDLGYTSVFPASILHDPSSAIPNRTVPPSVAEDPTSLSDWHMFHISEPPTSLLLTLTSSMASIKVFPTDNTTIQSVPTAVEKSTSVLLRRRYALVTSLSTVAVWGILINTLSVKNYLHIVDLVKKQISDAGKKSYLFVVGKINAAKVANFSEIGGWVVIGCWESSLIDSKDFYKPIITPFELQLALSPDSSRIWTGRWRSDFDTVLNATDAATTAADEGLTDEEGELFGSDDESEPPEFDLRTGRYITKTRPMGVSRKRQQAVTSNGPSSSTALAKRTGGDIVSVNGVASPAAEFLSQNRTWRGLEVRYDEDEDEDQGGLLEEGRTGVARGYTVGESGTT",
        "proteome": "UP000030752",
        "gene": "HMPREF1541_06478",
        "go_terms": [
            {
                "identifier": "GO:0090560",
                "name": "2-(3-amino-3-carboxypropyl)histidine synthase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0017183",
                "name": "protein histidyl modification to diphthamide",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "3a7bb4719785c490f9695451c41f9eb2b83c367f",
        "counters": {
            "domain_architectures": 10011,
            "entries": 13,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 0,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "ncbifam": 2,
                "cathgene3d": 2,
                "sfld": 3,
                "panther": 1,
                "pfam": 1,
                "interpro": 4
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 10011
        }
    }
}