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{
    "metadata": {
        "accession": "Q9LX30",
        "id": "GCN2_ARATH",
        "source_organism": {
            "taxId": "3702",
            "scientificName": "Arabidopsis thaliana",
            "fullName": "Arabidopsis thaliana (Mouse-ear cress)"
        },
        "name": "eIF-2-alpha kinase GCN2",
        "description": [
            "Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 eIF-2-alpha in response to low amino acid availability. Plays a role as an activator of the general amino acid control pathway required for adapatation to amino acid starvation. Converts phosphorylated eIF-2-alpha either to a competitive inhibitor of translation initiation, leading to a global protein synthesis repression, and thus to a reduced overall utilization of amino acids, or to a translational initiation activation of specific mRNAs, and hence allowing reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Binds uncharged tRNAs"
        ],
        "length": 1241,
        "sequence": "MGRSSSKKKKKRGGSGRRGQLKDHGSNADEDNELLSEEITALSAIFQEDCKVVSDSRSPPQIAIKLRPYSKDMGYEDTDISAMLIVRCLPGYPYKCPKLQITPEQGLTTADAEKLLSLLEDQANSNAREGRVMIFNLVEAAQEFLSEIIPESHDEESVPCLTAHRSTQFIEQPMLSNIAKSCSGGPFVYGFIDLFSGLEDARNWSLTPDENRGIVSSVQSHPLDTSRILHQKPDKNLKRFEDHAKEEVALPAPIAKLNTVQEENVDDTSISSFDSSKSTDDVESGLFQNEKKESNLQDDTAEDDSTNSESESLGSWSSDSLAQDQVPQISKKDLLMVHLLRVACTSRGPLADALPQITDELHELGILSEEVLDLASKSSPDFNRTFEHAFNQNMASTSVPQFWEPPSDSCEPNASLPSSRYLNDFEELKPLGQGGFGHVVLCKNKLDGRQYAVKKIRLKDKEIPVNSRIVREVATLSRLQHQHVVRYYQAWFETGVVDPFAGANWGSKTAGSSMFSYSGAVSTEIPEQDNNLESTYLYIQMEYCPRTLRQVFESYNHFDKDFAWHLIRQIVEGLAHIHGQGIIHRDFTPNNIFFDARNDIKIGDFGLAKFLKLEQLDQDGGFSTDVAGSGVDSTGQAGTYFYTAPEIEQDWPKIDEKADMYSLGVVFFELWHPFGTAMERHVILTNLKLKGELPLKWVNEFPEQASLLRRLMSPSPSDRPSATELLKHAFPPRMESELLDNILRIMQTSEDSSVYDRVVSVIFDEEVLEMKSHQSSRSRLCADDSYIQYTEINTELRDYVVEITKEVFRQHCAKHLEVIPMRLLSDCPQFSRKTVKLLTNGGDMLELCYELRLPFVHWISVNQKSSFKRYEISHVYRRAIGHSPPNPCLQADFDIVGGTLSLTEAEVLKVIVDITTHIFHRGSCDIHLNHGDLLDAIWSWAGIKAEHRRKVAELLSMMGSLRPQSSERKLKWVFIRRQLLQELKLPEAVVNRLQTVASRFCGDADQALPRLRGALRADRPTRKALDELSNLLTYLRVWRIEEHVHIDVLMPPTESYHRNLFFQVFLTKENSSGTSNDGVLLAVGGRYDWLVQEVCDREHKMNLPGAVGVSLALETIFQHLPMDLRPIRNEVSTSVLVCSRGGGGLLVQRMELVAELWEKSIKAEFVPTPDPSLTEQYEYANEHEIKCLVIITESGVAQNQIEFVKVRHLELKKEKVVGREELVKFLLDAMAVQFRNPSVWS",
        "proteome": "UP000006548",
        "gene": "GCN2",
        "go_terms": [
            {
                "identifier": "GO:0005515",
                "name": "protein binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0004672",
                "name": "protein kinase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0005524",
                "name": "ATP binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006468",
                "name": "protein phosphorylation",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 2,
        "source_database": "reviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "19c3adc8305c599fa032851ad74da8150e4674fe",
        "counters": {
            "domain_architectures": 407,
            "entries": 31,
            "isoforms": 1,
            "proteomes": 1,
            "sets": 5,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 5,
                "ssf": 4,
                "pfam": 4,
                "cdd": 2,
                "smart": 1,
                "profile": 2,
                "panther": 1,
                "prosite": 2,
                "interpro": 10
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 407
        }
    }
}