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{
    "metadata": {
        "accession": "Q9ICD1",
        "id": "Q9ICD1_HASV4",
        "source_organism": {
            "taxId": "35300",
            "scientificName": "Human astrovirus-4",
            "fullName": "Human astrovirus-4 (HAstV-4)"
        },
        "name": "Capsid polyprotein VP90",
        "description": [
            "[Capsid polyprotein VP70]: The immature virion is composed of 180 VP70 subunits with 90 dimeric spikes and displays a T=3 icosahedral symmetry. During maturation, VP70 undergoes a loss of 60 peripentonal spikes, which likely plays an important role in viral infectivity",
            "[Capsid polyprotein VP90]: The capsid polyprotein VP90 self-assembles and undergoes a proteolytic cleavage by host caspases to yield the immature VP70 virion",
            "[Core protein VP34]: Self-assembles to form an icosahedral capsid with a T=3 symmetry, about 43 nm in diameter. This forms contains only 30 spikes located on the icosahedral 2-fold axes",
            "[Spike protein VP25]: VP25 and VP27 Forms the spikes at the surface of the virion. This forms contains only 30 spikes located on the icosahedral 2-fold axes. Plays a role in the attachment to target host cell. This attachment induces virion internalization through clathrin-dependent endocytosis",
            "[Spike protein VP27]: VP25 and VP27 Forms the spikes at the surface of the virion. This forms contains only 30 spikes located on the icosahedral 2-fold axes. Plays a role in the attachment to target host cell. This attachment induces virion internalization through clathrin-dependent endocytosis"
        ],
        "length": 771,
        "sequence": "MASKSDKQVTVEVNNNGRSRSKSRARSQSRGRGRSVKITVNSHNKGRRQNGRNKYQSNQRVRKIVNKQLRKQGVTGPKPAICQTATATLGTIGSNTTGATEIEACILLNPVLVKDATGSTQFGPVQALGAQYSMWKLKYLNVRLTSMVGASAVNGTVVRISLNPTSTPSSTSWSGLGARKHLDVTVGKNAVFKLKPSDLGGPRDGWWLTNTNDNASDTLGPSIEIHTLGQTMSSYQNTQFTGGLFLVELSSAWCFTGYAANPNLVNLVKSTDKSVDVTFEGSAGTPLIMNVPEHSHFARMAVEHSSLSTSLSRAGGESSSDTVWQVLNTAVSAAELVTPPPFNWLVKGGWWFVKLIAGRARTGARRFYVYPSYQDALSNKPALCTGGVSAYTRQSNPVRTTLQFTQMNQPSLGHGATPATLGRSIPEPGDQFKVIMTAGALVQPNRSDSQNWLFKTVTPPTGHDAARVGWNTQHYLTIQGFLLIDSLEWLTPNLQESQEPPSIPELGVYVGIHKKALVYFMQQYVNPHTNNKHQVSSIFLIKPTENFSVTNYMSYFFRESQSDQNVANLKIRPQTWQQTVNFQRGKWYLVTNTAIRNGPPPSGWIWDNMELTNENIYYADQVLAHFINPPPQDSKLYFEVHTTMPQSSMRNVGFDEDQTDNWQEPDEDLQTSTEESDYETDSLEDESDDEDTYTSRELVINTLVNQGISRDRATYIGMSAYPNVEWGSGEKSTSQHISEIPSDDVGVEAHCTCACERKQQSLSQGSRGHAE",
        "proteome": null,
        "gene": null,
        "go_terms": null,
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": false,
        "in_bfvd": false,
        "ida_accession": "983e5a4fdafef0ef1315c174827562aa7a5a5b4a",
        "counters": {
            "domain_architectures": 245,
            "entries": 6,
            "isoforms": 0,
            "proteomes": 0,
            "sets": 2,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "pfam": 2,
                "cathgene3d": 1,
                "interpro": 3
            },
            "proteome": 0,
            "taxonomy": 1,
            "similar_proteins": 245
        }
    }
}