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{
    "metadata": {
        "accession": "Q98862",
        "id": "IHH_DANRE",
        "source_organism": {
            "taxId": "7955",
            "scientificName": "Danio rerio",
            "fullName": "Danio rerio (Zebrafish)"
        },
        "name": "Indian hedgehog B protein",
        "description": [
            "Signal involved in the early induction and patterning of anterodorsal ectoderm, nervous system and somites (By similarity). It is involved in the regulation of endochondral skeleton formation, and the development of retinal pigment epithelium (RPE), photoreceptors and periocular tissues (By similarity)",
            "The C-terminal part of the indian hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product (By similarity). Both activities occur in the endoplasmic reticulum (By similarity)",
            "The dually lipidated indian hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development. Binds to the patched (PTCH1) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes (By similarity). In the notochord, induces somite patterning and muscle pioneer differentiation (PubMed:8684485)"
        ],
        "length": 412,
        "sequence": "MRLSTAAALLTGFILAFSPAYDGCGPGRGYGKRRTPRKLTPLAYKQFSPNVAEKTLGASGRYEGKVTPSSERFKELTPNYNPDIIFKDEENTGADRMMTQRCKDKLNSLAISVMNLWPGVRLRVTEGWDEDGLHSEESLHYEGRAVDITTSDRDRNKYRMLARLAVEAGFDWVYYESKGHVHCSVKSEHSVAAKTGGCFPGRALVTMKDGSHRQIRDLQAGDLVLASEGSDGTGDLIYSEVLTFLDRRPITQKHFYVIRTEDGASVSLTAAHLLFMRVGNCSNRGEPKPGAVRTIFASDAQVGQCLLLGKLRKRFSQITHVGVREDQGLYPPLTAHGTVVVNDVLTSCYAAVNRQRLAHWAFAPLRLLYSWTGPDQVLKNGLHWYSQVLIGLGKLLLDSELFHPLALEATER",
        "proteome": "UP000000437",
        "gene": "ihhb",
        "go_terms": [
            {
                "identifier": "GO:0007267",
                "name": "cell-cell signaling",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0016540",
                "name": "protein autoprocessing",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0016539",
                "name": "intein-mediated protein splicing",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0007275",
                "name": "multicellular organism development",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 2,
        "source_database": "reviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "a73b552ecc23d61627e97e1396c48fbde1a4af23",
        "counters": {
            "domain_architectures": 2934,
            "entries": 22,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 3,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 2,
                "pfam": 2,
                "ssf": 2,
                "smart": 2,
                "profile": 1,
                "cdd": 1,
                "pirsf": 1,
                "panther": 1,
                "prints": 1,
                "interpro": 9
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 2934
        }
    }
}