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{
    "metadata": {
        "accession": "Q8MZM6",
        "id": "Q8MZM6_ANOGA",
        "source_organism": {
            "taxId": "7165",
            "scientificName": "Anopheles gambiae",
            "fullName": "Anopheles gambiae (African malaria mosquito)"
        },
        "name": "thioredoxin-disulfide reductase (NADPH)",
        "description": [
            "Thioredoxin system is a major player in glutathione metabolism, due to the demonstrated absence of a glutathione reductase. Functionally interacts with the Sod/Cat reactive oxidation species (ROS) defense system and thereby has a role in preadult development and life span. Lack of a glutathione reductase suggests antioxidant defense in Drosophila, and probably in related insects, differs fundamentally from that in other organisms"
        ],
        "length": 502,
        "sequence": "MAPLNQENYEYDLVVIGGGSGGLACAKQAVQLGAKVAVLDFVKPSPRGTKWGLGGTCVNVGCIPKKLMHQASLLGEAIHDSQPYGWQLPDPAAIRHDWATLTESVQNHIKSVNWVTRVDLRDQKVEYVNGLGYFKDDHTVVAVMKNQTERELRAKHVVIAVGGRPRYPDIPGAAEYGITSDDIFSLPQAPGRTLLVGAGYIGLECAGFLKGLGYDVSVMVRSILLRGFDQQMATMVGDSMVEKGIRFHHRSRPLAVEKQPDGRLLVRYETVDEAGTATNGEDVFDTVLFAIGRQAETGTLKLANAGVVTAEGGKSDKLEVDETDHRTNVPHIYAVGDVLYRKPELTPVAIHAGRIIARRLFGGSEERMDYADVATTVFTPLEYGCVGLSEEAAEAAHGKDGIEVYHAYYKPTEFFVPQRSVRYCYLKAVALREGNQRVLGLHFLGPAAGEVIQGFAAALKCGLTMQVLRNTVGIHPTVAEEFTRLAITKRSGLDPTPATCCS",
        "proteome": "UP000007062",
        "gene": "trxR",
        "go_terms": [
            {
                "identifier": "GO:0016491",
                "name": "oxidoreductase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0050660",
                "name": "flavin adenine dinucleotide binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0045454",
                "name": "cell redox homeostasis",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0004791",
                "name": "thioredoxin-disulfide reductase (NADPH) activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0016668",
                "name": "oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "protein_evidence": 2,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "786e6e0af388e0b289d71a3e92e80414d4c849c2",
        "counters": {
            "domain_architectures": 105347,
            "entries": 20,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 2,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "ssf": 2,
                "pfam": 2,
                "cathgene3d": 2,
                "pirsf": 1,
                "panther": 1,
                "ncbifam": 1,
                "prints": 2,
                "prosite": 1,
                "interpro": 8
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 105347
        }
    }
}