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{
    "metadata": {
        "accession": "Q8AVG2",
        "id": "Q8AVG2_XENLA",
        "source_organism": {
            "taxId": "8355",
            "scientificName": "Xenopus laevis",
            "fullName": "Xenopus laevis (African clawed frog)"
        },
        "name": "Protein phosphatase 1A",
        "description": [
            "Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB"
        ],
        "length": 383,
        "sequence": "MGAFLDKPKMEKHNAHGQGNELRYGLSSMQGWRVEMEDAHTAAIGLPNGLDAWSFFAVYDGHAGSQVAKYCCEHLLDHITSNQDFKGTDGHLSVWSVKNGIRTGFLQIDEHMRVISEKKHGADRSGSTAVGVMLSPNHIYFINCGDSRGLLCRSKKVHFFTQDHKPSNPLEKERIQNAGGSVMIQRVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPEPEVYEIERSEEDDQFIILACDGIWDVMGNEELCDFVGSRLEVTDDLERVCNEIVDTCLYKGSRDNMSVILICFPSAPKVLPEAVKREAELDKYLEGRVEDIIKKQGEEGVPDLVHVMRTLASENIPHLPPGGELASKRSVIEAVYNRLNPYRNDDTDSASTDDMW",
        "proteome": "UP000186698",
        "gene": "ppm1a.S",
        "go_terms": [
            {
                "identifier": "GO:0000287",
                "name": "magnesium ion binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0004721",
                "name": "phosphoprotein phosphatase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0030145",
                "name": "manganese ion binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0004722",
                "name": "protein serine/threonine phosphatase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006470",
                "name": "protein dephosphorylation",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0043169",
                "name": "cation binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "protein_evidence": 2,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "6f03d9f1aa22bd168030dc5029ba03af33e54c17",
        "counters": {
            "domain_architectures": 4224,
            "entries": 17,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 2,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 2,
                "ssf": 2,
                "smart": 1,
                "profile": 1,
                "cdd": 1,
                "pfam": 2,
                "panther": 1,
                "prosite": 1,
                "interpro": 6
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 4224
        }
    }
}