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{
    "metadata": {
        "accession": "Q6DFV5",
        "id": "HELZ_MOUSE",
        "source_organism": {
            "taxId": "10090",
            "scientificName": "Mus musculus",
            "fullName": "Mus musculus (Mouse)"
        },
        "name": "ATP-dependent RNA helicase with zinc finger domain",
        "description": [
            "ATP-dependent RNA helicase that promotes degradation of mRNAs via its association with the CCR4-NOT deadenylase complex, leading to deadenylation, decapping, and subsequent degradation of target mRNAs. Can repress translation independently of mRNA decay in a manner dependent on both the CCR4-NOT complex and the helicase DDX6. Involved in promoting cell proliferation, translation initiation, and ribosomal protein S6 (RPS6) phosphorylation"
        ],
        "length": 1964,
        "sequence": "MEDRRAERSCEQACASLQRQDYDMALQHCTDALLSLGQYSMADFTGPCPVEVERIKIESLLYRIASFLQLKNYGQADEDCRHVLGEGLAKGERAFRAVLCCMQLKGKLQLVSSILAKSLSGESLNGMVTKDLTRLKTLLTETETATSNVLSGCHVEDLDEGSCNGWHFRPPPRGITSSEEYTLCKRFLEQGICRYGAQCTSAHSQEELAEWQKRYASRLIKLKQQSENKQLSGSYMETLIEKWMSSLSPEKVLSECIEGVQVEHSPDLSVTVNTKKSHQTWTFALTCKPARMLYRVALLYDAHRPHFSIIAISAGDSTTQVSQEVPENCQEWIGGKMAQNGLDHYVYKVGIAFNTEIFGTFRQTIVFDFGLEPVLMQRVMIDAASTEDLEYLMHAKRQLVTTAKRWDSSSKTIVDFEPNETTDLEKSLLIRYQIPLSADQLFTQSVLDKSLTKTNYQARLHDLLYIEEIAQYKEVSRFNLKVQLQILASFMLTGVSGGAKYAQNGQLFGRFKLTETLSEDTLAGRLVMTRVNAVYLLPVPKEKLVQSQGTKEKVYEATIEEKTKDYVFLRISRECCEELSLRPDCDIQVELQFQLNRLPLCEMHYALDRIKDNAVLFPDISMTPTIPWSPNRQWDEQLDPRLNAKQKEAVLAITTPLSIQLPPVLIIGPYGTGKTFTLAQAAKHILQQQETRILICTHSNSAADLYIKDYLHPYVEAGNPQARPLRVYFRNRWVKTVHPVVHQYCLISSTQSTFQMPQKEDILKHRVVVVTLSTSQYLCQLDLEPGFFTHVLLDEAAQAMECETIMPLALATKNTRIVLAGDHMQLSPFVYSEFARERNLHVSLLDRLYEHYPAEFPCRILLCENYRSHEAIINYTSELFYEGKLMASGKQPAHKDFYPLTFFTARGEDVQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWGKLDDGSIGVVTPYADQVFRIRAELRKKRLSDVNVERVLNVQGKQFRVLFLSTVRTRHTCKHKQTPIKKKEQLLEDSTEDLDYGFLSNYKLLNTAITRAQSLVAVVGDPVALCSIGRCRKFWERFIALCHENHSLHGITFEQIKAQLEALELKKTYVLNPLAPEFIPRALRLQHSGNSSRQQQSPPKVKSLYHPQSDHFQSDGIVQPNPSVLIGNPIRAYTPPPPLGPHPNLGKSPSPVQRIDPHTGTSILYVPAVYGGNVVMSVPLPVPWTGYQGRFAVDPRIITHQAAMAYNMNLLHTHGRGSPIPYGLGHHPPVSLGQPQSQHAEKDQQEQNRNGKTDTNNPGPEINKIRTPEKKPTEPKQVDLESNPQNRSPESRPGVVYSNTKFPRKDHLNPRHINNLPLPAPHAQYAIPSRHFHPLPQLPRPPFPASQPHTLLNQQQNNLPEQPNQMAPQPNQVAPQPNQMTPQPNQVAPQPNQVVQQQSQAPPQAPQPAPQLSPAFQAGPTNAFFNNAVAHRPQSPAAEAVGPEQPPPPGLPDGHSPLRAITQPGPILASPLNNFVDESSPGLPIEEALDGVHGSVALETLRQQQARLQQWSEHHAYLSQGGIPYSHHHHPHLPHLPHTPIGLHQPPVRAEWKVAGRADDETETTFSRFQDLLRELSHRDQGDTGELAEMPPPQSRLLQYRQVQPRSPPAVPSPPSSTDHSSQFANFNDSSRDIEVANSPAFPQRLPPQLFGSPFSLPSEHLAPPPLKYLAPEGAWNFANLQQNHLIGPGFPYGLPPLPPRPPQNPFIHIQNHQHAAGQEPFHPLSSRTVSASSLPSLEEYEPRGPGRPLYQRRISSSSAQPCVEEASAPQDSLAQGKESQGHSNPPAFNFPAPESWANTTSSAPYQNIPCNGSSRTSQPRELIAPPKTVKPPEDQLKPESGEVSSSFNYSMLQHLGQFPPLMPNKQIAESANCSSQQSPAGSKPAMSYASALRAPPKPRPPPEQAKKGSDPLSLLQELSLGSSPGSNGFYSYFK",
        "proteome": "UP000000589",
        "gene": "Helz",
        "go_terms": [
            {
                "identifier": "GO:0046872",
                "name": "metal ion binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0004386",
                "name": "helicase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0003677",
                "name": "DNA binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0005524",
                "name": "ATP binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0016787",
                "name": "hydrolase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "protein_evidence": 1,
        "source_database": "reviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "af4b809d0e2789c0788ca42ae8edb2fc08c64af7",
        "counters": {
            "domain_architectures": 126,
            "entries": 22,
            "isoforms": 3,
            "proteomes": 1,
            "sets": 4,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "smart": 1,
                "profile": 1,
                "ssf": 2,
                "cathgene3d": 2,
                "cdd": 2,
                "pfam": 4,
                "panther": 1,
                "interpro": 9
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 126
        }
    }
}