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{
    "metadata": {
        "accession": "Q6DFE8",
        "id": "Q6DFE8_XENLA",
        "source_organism": {
            "taxId": "8355",
            "scientificName": "Xenopus laevis",
            "fullName": "Xenopus laevis (African clawed frog)"
        },
        "name": "Tyrosyl-DNA phosphodiesterase 1",
        "description": [
            "DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate"
        ],
        "length": 597,
        "sequence": "MDRTSASQQSNYGKWTLSSSEDEAEDSTIPSTPSSSRQSLDSVPHYTCSDARKASHKRKVNPVKFEEMSKQESIPAKKIKTESEVSGWCLSSSDEESKPTQSEQKKKIKTDTIDAPVRAQNIQGHTEVTQVKYKTPSDSQDIWDLLQAGEPFRFYLTKVTGIKPKYNSGALHIKDILSPLFGTLVSSAQFNYCFDIEWLVKQYPEEFRNKPLLIVHGEKRESKTKLHEDAHPYEHIRLCQAKLDIAYGTHHTKMMLLLYTEGLRVVIHTSNLIREDWYQKTQGIWLSPLYPRLPEGASVSAGESSTNFRSDLIAYLASYNSPSLREWMDIIKQHDLSETRVYLIGSTPGRFQGKDKDKWGHFRLRKLLRENTSAGPDKEMWPVIGQFSSIGSMGVDKTKWLCSEFTESLKTLGKSIKSLQKSEIPLRLIYPSVDNVRTSLEGYPAGGSLPYSIQTAQKQPWLHSYFHKWKAETSGRSQAIPHIKTYMRFSPDFQNLAWFLVTSANLSKAAWGSLEKNGAQLFIRSYELGVLFLPSAFDTNTFNVKVNIYSHNEPSGNAFPVPYDLPPEHYGSKDRPWVWNIPYVNAPDTHGNIWCPP",
        "proteome": "UP000186698",
        "gene": "tdp1.L",
        "go_terms": [
            {
                "identifier": "GO:0008081",
                "name": "phosphoric diester hydrolase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006281",
                "name": "DNA repair",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0005634",
                "name": "nucleus",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            }
        ],
        "protein_evidence": 2,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "6047af90a04d599ec7aba9e7c46b223aea6dd18c",
        "counters": {
            "domain_architectures": 4974,
            "entries": 7,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 2,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "ssf": 1,
                "cathgene3d": 1,
                "cdd": 2,
                "panther": 1,
                "pfam": 1,
                "interpro": 1
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 4974
        }
    }
}