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{
    "metadata": {
        "accession": "Q5LSI0",
        "id": "Q5LSI0_RUEPO",
        "source_organism": {
            "taxId": "246200",
            "scientificName": "Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3)",
            "fullName": "Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3)"
        },
        "name": "Thiamine pyrimidine synthase",
        "description": [
            "Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme"
        ],
        "length": 364,
        "sequence": "MSPFGTLPKGVRLIPYPTRSRTEPGQRNRQPTRSEIMKKLMNGAALALALAAGPALAADEVKLQLQWVTQAQFAGYYVALDKGFYDEEGLDVTILPGGPDIAPPQVLAGGGADAMLNWMPSALAAREKGLPVVNIAQPFKSSGLMLTCWKDTGITGPQDFKGKTIGVWFFGNEYPFLSWMSQEGISTDGGADGVTVLKQGFNVDPLLQRQADCISTMTYNEYGQVLDAGVSEDELVTFKYEDMGVATLEDGIYVLEDNLKDEAFKDKMTRFVRASMKGWKYAEANPDEAAGIVLDNDATGAQTEAHQVRMMGEIAKLTAGSNGALDPADFDRTVGTLLAGGSDPVITKTPEGAWTHEITDAALK",
        "proteome": "UP000001023",
        "gene": "SPO1788",
        "go_terms": [
            {
                "identifier": "GO:0009228",
                "name": "thiamine biosynthetic process",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "a7843b174854e51b1f7bf70c154a1e948dc81e7c",
        "counters": {
            "domain_architectures": 65119,
            "entries": 6,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 1,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "ssf": 1,
                "cathgene3d": 1,
                "panther": 1,
                "pfam": 1,
                "interpro": 2
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 65119
        }
    }
}