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{
    "metadata": {
        "accession": "Q4E409",
        "id": "VTC4_TRYCC",
        "source_organism": {
            "taxId": "353153",
            "scientificName": "Trypanosoma cruzi (strain CL Brener)",
            "fullName": "Trypanosoma cruzi (strain CL Brener)"
        },
        "name": "Vacuolar transporter chaperone complex subunit 4",
        "description": [
            "Component of a polyphosphate synthase complex that utilizes ATP to synthesize and translocate polyphosphate to acidocalcisomes in epimastigotes, insect-stages of Trypanosoma brucei (PubMed:24386955). Catalytic subunit of the vacuolar transporter chaperone (VTC) complex. The VTC complex acts as a vacuolar polyphosphate polymerase that catalyzes the synthesis of inorganic polyphosphate (polyP) via transfer of phosphate from ATP to a growing polyP chain, releasing ADP. VTC exposes its catalytic domain vtc4 to the cytosol, where the growing polyP chain winds through a tunnel-shaped pocket, integrating cytoplasmic polymer synthesis with polyP membrane translocation. The VTC complex carries 9 vacuolar transmembrane domains, which are likely to constitute the translocation channel into the organelle lumen. PolyP synthesis is tightly coupled to its transport into the vacuole lumen, in order to avoid otherwise toxic intermediates in the cytosol, and it depends on the proton gradient across the membrane, formed by V-ATPase. The VTC complex also plays a role in vacuolar membrane fusion (By similarity). Essential for infection and parasite survival in the mammalian host (By similarity)"
        ],
        "length": 801,
        "sequence": "MPFSKAWRSAVYPDFREQGAYINYKATKDILHRMKEDIANPSTPDELYNSLLLQKCRVYKWCEKKIKELLTVAEALMAASDYLTEEDTKTNLSLVLNTLGSGNMKCLPPNEARLLADSITHELLRFVECCNLNTDTIEHIIGRMYRYAVLGPTGKHWNNIMTEYDYHKLSIHEIFYLLSKVYDRVTATENMRIVKRSGIPAGTVGSQVFDRRSVKYWVHLQDLPFVIARIIPHLPHSTFKETYQTCKERNIPFTLGSPVSSVYWDNNEFLLYHRRLERLEGATLIRMRWYGDPLENDWNKLGPNDSVFMEIKVHHEAWSGERSNKRRFALKEKEVNSYVHGELDLNPALEKLRAKKASKKELHNFMDLSTEIVTKIDAYDLKPVIRTQCSRAAFQRGIDQSIRVSIDTDLRVCAEDFGLGHHWRYSGVDAPVSYFPYAVVEIKLQCAENERIAPWIEELMSCRYMESVPKFSKYAHGIASLYGHTPFIKMVPYWMHQLDIDIRASTKPEQNQWDPTVGLASGCWERTTDRAIFGVGHAQTQTVGASEAQFLPRTDYTRVYQKALHGIRGEGVATPATADNFQDAEAEGGCASGTAGSRKQQLQPRLPAHTLQYDVDRRHKAYTTFHLYPFAEYGVESLCFTPASGKNAAAEVLSGLIPWQTGKRIRVPQKYDPKTLLTSERYMLKWTEHATRLGLVGLGVIQFGNSMTLPGDVTQLSSFWRANFHIVLGIALVLVALMTLMYALMTFKARSRRVYARKKIRFDDSWGPTVLTVFLAFGICVIAMMHILGRYGPMLTGDDNF",
        "proteome": "UP000002296",
        "gene": "Tc00.1047053511127.100",
        "go_terms": null,
        "protein_evidence": 1,
        "source_database": "reviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "0c28cb1310810344dbe1908e0a4850e3471d3d6b",
        "counters": {
            "domain_architectures": 2797,
            "entries": 9,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 2,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cdd": 1,
                "pfam": 2,
                "cathgene3d": 1,
                "panther": 1,
                "interpro": 4
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 2797
        }
    }
}