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{
    "metadata": {
        "accession": "Q45EK2",
        "id": "CEH60_CAEEL",
        "source_organism": {
            "taxId": "6239",
            "scientificName": "Caenorhabditis elegans",
            "fullName": "Caenorhabditis elegans"
        },
        "name": "Homeobox protein ceh-60",
        "description": [
            "Probable transcription regulator which binds to DNA, repressing genes involved in longevity and stress, while activating genes involved in reproduction, such as the vitellogenins (PubMed:30956009, PubMed:31675356). Associates with homeobox unc-62 to regulate gene expression, including repression of genes involved in innate immunity (PubMed:30956009, PubMed:31675356). Required for intestinal expression of vitellogenin genes (PubMed:30956009, PubMed:31675356). Negatively modulates longevity, probably independently of effects on vitellogenesis (PubMed:30956009). Involved in lipid homeostasis, contributing to the reallocation of intestinal lipids to the germline and to the formation of the cuticle (PubMed:30956009, PubMed:31675356). Associates with transcriptional regulator pqm-1 at the daf-16 associated element within the promoters of stress-responsive genes to regulate expression (PubMed:30956009)"
        ],
        "length": 360,
        "sequence": "MDNLIKQLQMSVSSENVDRNFIEKCIEMNPCRRMLHEVLLERKDILRSRMNLVALYDTDEQSSEIEEILAQFENPTFPLEEVNTEKDEEWQPLERKYLDGINRIKEDTIMKQIQLDKDMEKALTNSEEVLRNHRDFRPIDEKDFSNIRQSISKRFEHSKNNIRGEAATKILVLRREIEQQGRKRRNFDKNTTDILQNWFHDHRQNPYPSDQEKAELAKQCNIKISQVNNWFGNQRIRTKQQALRMQEDERERAASMANEAQAIQNSLNSSTVASSSNMSTSGLINIPLVNPTMQSMVIPAVQPGLLGNPNAFLHQPHYFTAGGQMSLNDNGNGQQFFTDYETFGLAQSDTESFNQMGYLG",
        "proteome": "UP000001940",
        "gene": "ceh-60",
        "go_terms": [
            {
                "identifier": "GO:0003700",
                "name": "DNA-binding transcription factor activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0005634",
                "name": "nucleus",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            },
            {
                "identifier": "GO:0003677",
                "name": "DNA binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006355",
                "name": "regulation of DNA-templated transcription",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0000981",
                "name": "DNA-binding transcription factor activity, RNA polymerase II-specific",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "protein_evidence": 1,
        "source_database": "reviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "d7c4d5d1a2be6919771db15898c9cbe7f07b931c",
        "counters": {
            "domain_architectures": 6217,
            "entries": 16,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 2,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "profile": 2,
                "smart": 1,
                "ssf": 1,
                "cathgene3d": 1,
                "cdd": 1,
                "pfam": 2,
                "panther": 1,
                "prosite": 1,
                "interpro": 6
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 6217
        }
    }
}