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{
    "metadata": {
        "accession": "Q2U852",
        "id": "CSYB_ASPOR",
        "source_organism": {
            "taxId": "510516",
            "scientificName": "Aspergillus oryzae (strain ATCC 42149 / RIB 40)",
            "fullName": "Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)"
        },
        "name": "Acylalkylpyrone synthase csyB",
        "description": [
            "Acylalkylpyrone synthase that catalyzes not only the polyketide chain elongation but also the one-pot condensation of two beta-ketoacyl units to produce the 3-acyl-4-hydroxy-6-alkyl-alpha-pyrone (AcAP) scaffold, a precursor of csypyrone B (Probable) (PubMed:20471846, PubMed:23290452, PubMed:24011646, PubMed:24895122, PubMed:25564614). The enzyme reaction is initiated by the loading of acetoacetyl-CoA onto Cys-155, and subsequent thioester bond cleavage by the nucleophilic water generates the beta-keto acid intermediate, which is placed within a pocket (PubMed:25564614). The second beta-ketoacyl unit is then produced by polyketide chain elongation of fatty acyl-CoA with one molecule of malonyl-CoA, and the condensation with the beta-ketoacid generates the final products (PubMed:24895122, PubMed:25564614). Csypyrone B1 is the major product and contains a propanoic acid side-chain, whereas csypyrones B2 and B3 are minor compounds that contain butyric or pentanoic acid side-chains, respectively (PubMed:20471846, PubMed:23290452, PubMed:24011646)"
        ],
        "length": 397,
        "sequence": "MIEPLPTEDIPKQSVSIVGIASRCAPHKLGADELEAIARRHYSSTPSLEKMLEINRKTRIDHRYSVFSSDHEHWHRPTIPSFSECDSLFKEYGIPLASAASARAIQDWGGVPDEITHLVAVTCTNTAHPGFDSVLCRKLGLKCNVRRVLLHGIGCGGGISAMRVAHELLLGSTQQGVPARALIVACEVPTVFARSELDIMDKTQDVNVAMCLFGDCAAALVLSNGIGHKASEQRPIWNILNCEPTQFDGTEDIAHFNVHDKGYHAIIDKRIPQLTGKCVPAGFQSLISSTPSLALEEKNYVPSNYGWAVHPGGYAVLVAAQDALGLTADDLRASYDAYRDGGNTISTTIIRILEKLRDEHKHGSNQKDKLVLAAIGHGITLETAILTRPGSSSYLHA",
        "proteome": "UP000006564",
        "gene": "csyB",
        "go_terms": [
            {
                "identifier": "GO:0016746",
                "name": "acyltransferase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0016747",
                "name": "acyltransferase activity, transferring groups other than amino-acyl groups",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0009058",
                "name": "biosynthetic process",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 1,
        "source_database": "reviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "8b35207b412f63cbf238bee19f3fdffaffcc0a02",
        "counters": {
            "domain_architectures": 17176,
            "entries": 10,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 1,
            "structures": 3,
            "taxa": 1,
            "dbEntries": {
                "ssf": 1,
                "cathgene3d": 1,
                "pfam": 2,
                "pirsf": 1,
                "panther": 1,
                "interpro": 4
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 17176
        }
    }
}