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{
"metadata": {
"accession": "I7HD17",
"id": "I7HD17_9HEPC",
"source_organism": {
"taxId": "31649",
"scientificName": "Hepatitis C virus subtype 2a",
"fullName": "Hepatitis C virus subtype 2a"
},
"name": "Genome polyprotein",
"description": [
"Cysteine protease required for the proteolytic auto-cleavage between the non-structural proteins NS2 and NS3. The N-terminus of NS3 is required for the function of NS2 protease (active region NS2-3). Promotes the initiation of viral particle assembly by mediating the interaction between structural and non-structural proteins",
"Induces a specific membrane alteration that serves as a scaffold for the virus replication complex. This membrane alteration gives rise to the so-called ER-derived membranous web that contains the replication complex. NS4B self-interaction contributes to its function in membranous web formation. Promotes host TRIF protein degradation in a CASP8-dependent manner thereby inhibiting host TLR3-mediated interferon signaling. Disrupts the interaction between STING and TBK1 contributing to the inhibition of interferon signaling",
"RNA-dependent RNA polymerase that performs primer-template recognition and RNA synthesis during viral replication. Initiates RNA transcription/replication at a flavin adenine dinucleotide (FAD), resulting in a 5'- FAD cap on viral RNAs. In this way, recognition of viral 5' RNA by host pattern recognition receptors can be bypassed, thereby evading activation of antiviral pathways"
],
"length": 3033,
"sequence": "MSTNPKPQRKTKRNTNRRPQDVKFPGGGQIVGGVYLLPRRGPRLGVRATRKTSERSQPRGRRQPIPKDRRSTGKSWGKPGYPWPLYGNEGLGWAGWLLSPRGSRPSWGPNDPRHRSRNVGKVIDTLTCGFADLMGYIPVVGAPLGGVARALAHGVRVLEDGVNFATGNLPGCSFSIFLLALLSCITTPVSAAEVKNISTGYMVTNDCTNDSITWQLQAAVLHVPGCVPCEKVGNASQCWIPVSPNVAVQRPGALTQGLRTHIDMVVMSATLCSALYVGDLCGGVMLAAQMFIVSPQHHWFVQDCNCSIYPGTITGHRMAWDMMMNWSPTATMILAYAMRVPEVIIDIISGAHWGVMFGLAYFSMQGAWAKVVVILLLAAGVDARTHTVGGSAAQTTGRLTSLFDMGPRQKIQLVNTNGSWHINRTALNCNDSLHTGFIASLFYTHSFNSSGCPERMSACRSIEAFRVGWGALQYEDNVTNPEDMRPYCWHYPPRQCGVVSAKTVCGPVYCFTPSPVVVGTTDRLGAPTYTWGENETDVFLLNSTRPPLGSWFGCTWMNSSGYTKTCGAPPCRTRADFNASTDLLCPTDCFRKHPDTTYLKCGSGPWLTPRCLIDYPYRLWHYPCTVNYTIFKIRMYVGGVEHRLTAACNFTRGDRCNLEDRDRSQLSPLLHSTTEWAILPCSYSDLPALSTGLLHLHQNIVDVQFMYGLSPALTKYIVRWEWVILLFLLLADARVCACLWMLILLGQAEAALEKLVILHAASAASCNGFLYFVIFFVAAWYIKGRVVPLATYSLTGLWSFSLLLLALPQQAYAYDASVHGQIGAALLVMITLFTLTPGYKTLLGQCLWWLCYLLTLGEAMIQEWVPPMQVRGGRDGIAWAVTIFCPGVVFDITKWLLALLGPAYLLRAALTHVPYFVRAHALIRVCALVKQLAGGRYVQVALLALGRWTGTYIYDHLTPMSDWAASGLRDLAVAVEPIIFSPMEKKVIVWGAETAACGDILHGLPVSARLGQEILLGPADGYTSKGWKLLAPITAYAQQTRGLLGAIVVSMTGRDKTEQAGEIQVLSTVTQTFLGTTISGVLWTVYHGAGNKTLAGSRGPVTQMYSSAEGDLVGWPSPPGTKSMEPCTCGAVDLYLVTRNADVIPARRRGDKRGALLSPRPLSTLKGSSGGPVLCPRGHVVGIFRAAICSRGVAKSIDFIPVEAIDIVTRSPTFTDNSTPPAVPQTYQVGYLHAPTGSGKSTKVPVAYAAQGYKVLVLNPSVAATLGFGAYLAKAHGINPNIRTGVRTVTTGEAITYSTYGKFLADGGCAGGAYDIIICDECHATDATTLLGIGTVLDQAESAGVRLTVLATATPPGSITTPHPNIEEVALGQEGEIPFYGRAIPLAHIKGGRHLIFCHSKKKCDELAAALRAMGLNAVAYYRGLDVSIIPAQGDVVVVATDALMTGYTGDFDSVIDCNVAVTQVVDFSLDPTFTISTQTVPQDAVSRSQRRGRTGRGRLGIYRYVSTGERASGMFDSVTLCECYDAGAAWYDLTPAETTVRLRAYFNTPGLPVCQDHLEFWEAVFTGLTHIDAHYLSQTKQAGENFAYLTAYQATVCARAKAPPPSWDVMWKCLTRLKPTLVGPTPLLYRLGSVTNDVTFTHPVTKYIATCMQADLEVMTSTWVLAGGVLAAIAAYCLATGCVSIIGRLHVNQRTVVAPDKEVLYEAFDEMEECASRAALIEEAQRIAEMLKSKIQGLLQQASKQAQDIQPTVQASWPKVEQFWAKHMWNFISGIQYLAGLSTLPGNPAVASMMAFSAAITSPLSTSTTILLNIMGGWLASQIAPPAGATGFVVSGLVGAAIGSVGLGKVLVDILAGYGAGISGALVAFKIMSGEKPSMEDVINLLPGILSPGALVVGVICAAILRRHVGPGEGAVQWMNRLIAFASRGNHVAPTHYVTESDASQRVTQLLGSLTITSLLRRLHNWITEDCPTPCNGSWLRDVWDWVCTILTDFKNWLTSKLFPKLPGLPFISCQKGYRGDWAGTGIMVTRCPCGANISGNVRFGSMRITGPKTCMNTWQGTFPINCYTEGQCMPRPAPNFKTAIWRVAASEYAEVTRHGSYSYITGLTADNLKVPCQIPSPEFFSWVDGVQIHRFAPTPKPFFRDEVSFSVGLNSFVVGSQLPCDPEPDADVLMSMLTDPGHITAEAAARRLARGSPPSEASSSASQLSAPSLRATCATHGTAYDVAMVDANLFMKGEVIRIESDSKVVVLDSLDPLAEEVSDVEPSIPSEYLIPKKQFPPALPAWARPDYNPPLVESWRKPDYQPPTVAGCALPPPKKTPTPPPRKRRTVRLSESAVGDILQQLAIKTFGQPPPSGGPDPPTGAGAAGSGGQTPPDEPAPSETDSVSSMPPLEGEPGDPDLELGQVEPQPPPQGGEAAPDSDSGSWSTCSEEEDSTVCCSMSYSWTGALITPCSPEEEKLPINPLSNSLLRYHNKVYCTTSRSASLRAKKVTFDRMQVLDAHYDSVLKDIKLAASKVSARSLSLEEACKLTPPHSARSKYGFGAKEVRSLSGRAVNHIKSVWKDLLEDSQTPIPTTIMAKNEVFCVNPAKGGKKAARLIVYPDLGVRVCEKMALYDVAQKLPQAVMGASYGFQYSPAQRVEFLLKAWADKKDPMGFSYDTRCFDSTVTERDIRTEEDIYLSCSLPEEARTATHSLTERLYVGGPMFNSKGQTCGYRRCRASGVLTTSMGNTITCYVKALAACKAAGIVAPTMLVCGDDLVVISESQGTEEDERNLRAFTEAMTRYSAPPGDPPRPEYDLELITSCSSNVSVALGPRGNRRYYLTRDPTTPIARAAWETVRHSPVNSWLGNIIQYAPTIWVRMVLMTHFYSILMAQDTLDQNLNFEMYGAVYSVSPLDLPAIIEKLHGLDAFSLHTYSPNELTRVASALRKLGAPPLRAWKSRARAVRASLISRGGRAAVCGRYLFNWAVKTKLKLTPLPEARHLDLSSWFTVGAGGGDIYHSVSRARPRLLLLSLLLLFVGVGLFLLPAR",
"proteome": null,
"gene": null,
"go_terms": [
{
"identifier": "GO:0004197",
"name": "cysteine-type endopeptidase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0008236",
"name": "serine-type peptidase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0006508",
"name": "proteolysis",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0019087",
"name": "symbiont-mediated transformation of host cell",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0008270",
"name": "zinc ion binding",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0003968",
"name": "RNA-directed RNA polymerase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0039694",
"name": "viral RNA genome replication",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0005198",
"name": "structural molecule activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0019028",
"name": "viral capsid",
"category": {
"code": "C",
"name": "cellular_component"
}
},
{
"identifier": "GO:0019031",
"name": "viral envelope",
"category": {
"code": "C",
"name": "cellular_component"
}
},
{
"identifier": "GO:0016032",
"name": "viral process",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0044423",
"name": "virion component",
"category": {
"code": "C",
"name": "cellular_component"
}
},
{
"identifier": "GO:0004252",
"name": "serine-type endopeptidase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0017111",
"name": "ribonucleoside triphosphate phosphatase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0003723",
"name": "RNA binding",
"category": {
"code": "F",
"name": "molecular_function"
}
}
],
"protein_evidence": 3,
"source_database": "unreviewed",
"is_fragment": false,
"in_alphafold": false,
"in_bfvd": false,
"ida_accession": "fdbbd0c975d426b11f7f585a94169a6b41e4c969",
"counters": {
"domain_architectures": 26,
"entries": 67,
"isoforms": 0,
"proteomes": 0,
"sets": 3,
"structures": 0,
"taxa": 1,
"dbEntries": {
"cathgene3d": 14,
"cdd": 2,
"profile": 5,
"ssf": 3,
"pfam": 14,
"smart": 2,
"interpro": 27
},
"proteome": 0,
"taxonomy": 1,
"similar_proteins": 26
}
}
}
