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{
"metadata": {
"accession": "I3MWM3",
"id": "I3MWM3_ICTTR",
"source_organism": {
"taxId": "43179",
"scientificName": "Ictidomys tridecemlineatus",
"fullName": "Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)"
},
"name": "Sodium channel protein",
"description": [
"Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient",
"Sodium channel mediating the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Involved in membrane depolarization during action potential in nociceptors which function as key relay stations for the electrical transmission of pain signals from the periphery to the central nervous system. Also involved in rapid BDNF-evoked neuronal depolarization"
],
"length": 1763,
"sequence": "MDDRCYPVIFPDERNFRPFTSDSLAAIEKRIAAQKEKKKSKDKTVAEPQLRPQLDLKASRKLPKLYGNIPRDLIAKPLEDLDPYYRNHKTFMVLNKKRTIYRFSAKRALFILGPFNPLRSLAIRILVNSYPFATSSMFIICTVIVNCGLMASENNCTDIKENNSIAVIKILARGFILDEFSFLRDPWNWLDSIVIGTAIASYFPFKKINLLSLRTFRVFRALKAISVVSGLKVIVGALLRSVKKLVDVMVLTLFCLSIFALVGQQLFMGNLNQKCIRTNCTHNFEANEYCFEKEEDSKEPMLCGSWFGSRSCPNNSTCNHTRINPDNNYTSFDNFGWSFLAMFRLMTQDSWEKLYRQTLRTSGIYSVFFFVVVIFLGSFYLINLTLAVVTMAYEEQNRNVAAETEAKEKMFQEAQQLLKEEKEALVAMGIDRSSLNSLQASSFSPKKRKFFGNKKKKSLLKIKSRKDKTSGSDSDGEAPSNPPLLEQTKRLSQNLPVDLFDEHGDPFQRQRALSAVSILTITMHEQEKSQEPCLPCGENLASRYLVWNCSPWWLCVKKALRFVMTDPFTELAITICIIINTIFLSMEHHNMDPNLKSILQYGNWVFSGIFIAEMCLKIIALDPYHYFRQGWNIFDSIVALLSVAEVFFQGSKWSFLRSFRVLRVFKLAKSWPTLNTLIKIIGHSVGALGHLTVVLAIVIFIFSVVGVQLFGSKFCRQKSAHLCSVSEDPCLRRWHMGDFYHSFLVVFRILCGEWIENMWACMQEVNKPMCIIVFVLILIIGKLVVLNLFIALLLNSFSNEERYGISEGEARKTKVQLALDRFGRAFSFVIHTLEHFCCKRCKRHNLPKLKEMTADSDAESKDIIPLAADMKRGSEAQEEFGVLNSAQKTFSLGYDRSWLAPLAEEENDVEYFDKDDASSIMHSEAERQAYDLHQEKPAIPGDQSVEIDVFPEEEVYLAVQNPRKKSDAISIPSECSTIDLQEAFGYLYRIVPQQKQPERCLPKGLHCFFPCCRKDRRKSLWVIWWNLRKTCYQIVKHSWFESFIIFVILLSSGTLIFEDVHLDKRPHVREILNYTDHVFTYIFIFEMGLKWVAFGFGKYFTSAWCWLDFIIVIVSVVSLFTVNTWKPLRTLRALRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLIFCILGVNFFSGHFGRCISGKDKSKYLPYVENRSQCNETWVNLEVNFDNVGIAYLALLQVATYKGWLDIMEAAVDSRGEEKQPAFEAKPLMYLYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKISGQDIFMTEEQKKYYSAMKKLGTKKPQKPIPRPLNKCQGLVFDLVTHQVFDIFIMSLIVLNMVGMMAESYDQSEDVTVTFDYINIAFVIIFTIECLIKIFALRQYYFTNGWNLFDCVVVVLSIISTMVSALENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLVMFIYAILGMKFFSEVKKDAGIDNIFNFKTFEGSMLCLFQITTSAGWDSLLNPMLNSGDSGNATANSHLPAVATAYFVSYIIISFLIVVNMYIAVILENFNTATEESEDPLGEDDFEIFYEVWEKFDPEATQFIDYSALSDFADALPEPLRVAKPNKFQFLVMDLPMVSGDRLHCMDILFAFTTRVLGDSTGLDTMKAMMEEKFMEANPFRKLYEPIVTTTKRKEEERGAAIIQKAFRRYMMKMTKCALEDRPPASFQTLCNGDLSSSEGTKGKVHYD",
"proteome": "UP000005215",
"gene": "SCN11A",
"go_terms": [
{
"identifier": "GO:0005261",
"name": "monoatomic cation channel activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0005886",
"name": "plasma membrane",
"category": {
"code": "C",
"name": "cellular_component"
}
},
{
"identifier": "GO:0005216",
"name": "monoatomic ion channel activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0006811",
"name": "monoatomic ion transport",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0055085",
"name": "transmembrane transport",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0016020",
"name": "membrane",
"category": {
"code": "C",
"name": "cellular_component"
}
},
{
"identifier": "GO:0005248",
"name": "voltage-gated sodium channel activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0006814",
"name": "sodium ion transport",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0001518",
"name": "voltage-gated sodium channel complex",
"category": {
"code": "C",
"name": "cellular_component"
}
}
],
"protein_evidence": 3,
"source_database": "unreviewed",
"is_fragment": false,
"in_alphafold": false,
"in_bfvd": false,
"ida_accession": "ac6b276d1e20e335bfa33aba2ed7256b04ea46fa",
"counters": {
"domain_architectures": 2412,
"entries": 18,
"isoforms": 0,
"proteomes": 1,
"sets": 2,
"structures": 0,
"taxa": 1,
"dbEntries": {
"cathgene3d": 4,
"ssf": 1,
"cdd": 1,
"pfam": 3,
"panther": 1,
"prints": 1,
"interpro": 7
},
"proteome": 1,
"taxonomy": 1,
"similar_proteins": 2412
}
}
}
