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{
    "metadata": {
        "accession": "H9EXN2",
        "id": "H9EXN2_MACMU",
        "source_organism": {
            "taxId": "9544",
            "scientificName": "Macaca mulatta",
            "fullName": "Macaca mulatta (Rhesus macaque)"
        },
        "name": "Replication stress response regulator SDE2",
        "description": [
            "Inhibits translesion DNA synthesis by preventing monoubiquitination of PCNA, this is necessary to counteract damage due to ultraviolet light-induced replication stress. SDE2 is cleaved following PCNA binding, and its complete degradation is necessary to allow S-phase progression following DNA damage",
            "Plays a role in pre-mRNA splicing by facilitating excision of relatively short introns featuring weak 3'-splice sites (ss) and high GC content. May recruit CACTIN to the spliceosome",
            "Plays a role in ribosome biogenesis by enabling SNORD3- and SNORD118-dependent cleavage of the 47S rRNA precursor. Binds ncRNA (non-coding RNA) including the snoRNAs SNORD3 and SNORD118"
        ],
        "length": 451,
        "sequence": "MAEGAGLVWIRGPGFGCKAVRCASARCTVRDFIHRHCQDQDVPVENFFVKCNGALINSSDTVQHGAVYSLEPRLCGGKGGFGSMLRALGAQIEKTTNREACRDLSGRRLRDVNHEKAMAEWVKQQAEREAEKEQKRLERLQRKLVEPKHCFTSPDYQQQCHEMAERLEDSVLKGMQAASSKMVSAEISENRKRQWPAKSKTDRGASAGKRRCFWLGMEGLETAEGSSSESSDDDNEEAPSTSGMGFHAPKIGSDGVEMAAKFPSSSQRARVVNTDRGPPEQLQIPVTDSGRHISEDLCAGLGESKEHMESRIVTETEETQEKKAESKELIEEEPTGAGLSKDKETKERTDGERVAEVAPEERENVAVVKLQESQLGNTVIDKETIDLLAFSSVAELELLGLEKLKCELIALGLKCGGTLQERAARLFSVRGLAKEQIDPALFAKPLKGKKK",
        "proteome": "UP000006718",
        "gene": "SDE2",
        "go_terms": null,
        "protein_evidence": 2,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "ec795198a615100154e28ae17513c53a688293b1",
        "counters": {
            "domain_architectures": 668,
            "entries": 8,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 1,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "pfam": 3,
                "panther": 1,
                "interpro": 4
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 668
        }
    }
}