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InterPro-Version: 108.0
InterPro-Version-Minor: 0
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{
"metadata": {
"accession": "H0V8J4",
"id": "H0V8J4_CAVPO",
"source_organism": {
"taxId": "10141",
"scientificName": "Cavia porcellus",
"fullName": "Cavia porcellus (Guinea pig)"
},
"name": "Phospholipase A1 member A",
"description": [
"Hydrolyzes the ester bond of the acyl group attached at the sn-1 position of phosphatidylserines (phospholipase A1 activity) and 1-acyl-2-lysophosphatidylserines (lysophospholipase activity) in the pathway of phosphatidylserines acyl chain remodeling. Cleaves phosphatidylserines exposed on the outer leaflet of the plasma membrane of apoptotic cells producing 2-acyl-1-lysophosphatidylserines, which in turn enhance mast cell activation and histamine production. Has no activity toward other glycerophospholipids including phosphatidylcholines, phosphatidylethanolamines, phosphatidic acids or phosphatidylinositols, or glycerolipids such as triolein"
],
"length": 457,
"sequence": "MPWSLWERCFWLWGLLLWLGVRSAGDTPATSQPRCTDFQNASFLRGTNLRVQYLLFGPSDSGCGQLLEENSDIQNSGFNATLGTKLIIHGFRVLGTKPSWIDAFIRALLQATDANVIAVDWVYGSTGVYYSAVDNVVKLSLEISRFLSKLLVLGVSESSIHIIGVSLGAHVGGMVGHFYKGQLGRITGLDPAGPEYTRASLEERLDPGDALFVEAIHTDTDNLGIRIPVGHVDYFVNGGQDQPGCPLFIHAGYSYLICDHMRAVHLYISALENSCPLVAFPCANYKAFLAGQCLDCLNPFLLSCPRIGLLEQGGVKIEPLPKEVRVYLRTTSKAPYCVHHSLVEFYLQEPRKKDTSIEINFVSSNATSSIKVIIAKQQLRGKGIMAHPNPPCQIKQVKFKLQASSQVWRRDRTTIVGRFCTALLPVNDNKKTICLPQPVNLQESESVVHDWKTPCMT",
"proteome": "UP000005447",
"gene": "PLA1A",
"go_terms": [
{
"identifier": "GO:0016298",
"name": "lipase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0006629",
"name": "lipid metabolic process",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0052689",
"name": "carboxylic ester hydrolase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
}
],
"protein_evidence": 3,
"source_database": "unreviewed",
"is_fragment": false,
"in_alphafold": true,
"in_bfvd": false,
"ida_accession": "4b27ea83a55bae860624d8852585749e0e54f3f6",
"counters": {
"domain_architectures": 16973,
"entries": 12,
"isoforms": 0,
"proteomes": 1,
"sets": 2,
"structures": 0,
"taxa": 1,
"dbEntries": {
"pfam": 1,
"cathgene3d": 1,
"ssf": 1,
"cdd": 1,
"pirsf": 1,
"panther": 1,
"prints": 1,
"interpro": 5
},
"proteome": 1,
"taxonomy": 1,
"similar_proteins": 16973
}
}
}