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InterPro-Version: 108.0
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{
"metadata": {
"accession": "G7NPI8",
"id": "G7NPI8_MACMU",
"source_organism": {
"taxId": "9544",
"scientificName": "Macaca mulatta",
"fullName": "Macaca mulatta (Rhesus macaque)"
},
"name": "DnaJ homolog subfamily A member 3, mitochondrial",
"description": [
"Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway"
],
"length": 480,
"sequence": "MAARCSTRWLLVAVGTPRLPAALGRGARPPREGVVGAWLSRKLSVPAFASSLTSRGPRALLTLRPGVSLTGTIHYPFISTASFHTNAPLAKEDYYQILGVPRNASQKEIKKAYYQLAKKYHPDTNQDDPKAKEKFSQLAEAYEVLSDEVKRKQYDAYGSAGFDSGASGSQHSYWKGGPTVDPEELFRKIFGEFSSSSFGDFQTVFDQPQEYIMELTFNQAAKGVNKEFTVNIMDTCERCDGKGNEPGTKVQHCHYCGGSGMETINTGPFVMRSTCRRCGGRGSIIVTPCVVCRGVGQAKQKKRVMIPVPAGVEDGQTVRMPVGKREIFITFRVQKSPVFRRDGADIHSDLFISIAQALLGGTARAQGLYETINVMIPPGTQTDQKIRMGGKGIPRINSYGYGDHYIHIKIRVPKRLTSRQQNLILSYAEDETDVEGTVNGVTLTTSGGSSMDSSAGSKARREAGEDEEGFLSKLKKMFTS",
"proteome": null,
"gene": "EGK_12449",
"go_terms": [
{
"identifier": "GO:0031072",
"name": "heat shock protein binding",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0051082",
"name": "unfolded protein binding",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0006457",
"name": "protein folding",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0005524",
"name": "ATP binding",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0009408",
"name": "response to heat",
"category": {
"code": "P",
"name": "biological_process"
}
}
],
"protein_evidence": 3,
"source_database": "unreviewed",
"is_fragment": false,
"in_alphafold": true,
"in_bfvd": false,
"ida_accession": "009a4105d0b2ae9aa2aa7435e492b440f6147828",
"counters": {
"domain_architectures": 35801,
"entries": 28,
"isoforms": 0,
"proteomes": 0,
"sets": 5,
"structures": 0,
"taxa": 1,
"dbEntries": {
"cathgene3d": 3,
"ssf": 3,
"smart": 1,
"cdd": 3,
"pfam": 3,
"profile": 2,
"panther": 1,
"hamap": 1,
"prints": 1,
"prosite": 1,
"interpro": 9
},
"proteome": 0,
"taxonomy": 1,
"similar_proteins": 35801
}
}
}