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{
"metadata": {
"accession": "G4WWA9",
"id": "G4WWA9_9POTY",
"source_organism": {
"taxId": "137475",
"scientificName": "Cucumber vein yellowing virus",
"fullName": "Cucumber vein yellowing virus"
},
"name": "Gp1",
"description": [
"An RNA-dependent RNA polymerase that plays an essential role in the virus replication",
"Has RNA-binding and proteolytic activities",
"Indispensable for virus replication",
"Mediates the cap-independent, EIF4E-dependent translation of viral genomic RNAs. Binds to the cap-binding site of host EIF4E and thus interferes with the host EIF4E-dependent mRNA export and translation. VPg-RNA directly binds EIF4E and is a template for transcription. Also forms trimeric complexes with EIF4E-EIF4G, which are templates for translation"
],
"length": 3148,
"sequence": "MTEVYSFVPKTDYEKRMVKRFGTDKFLQFREQCPLNQVRKCWTHFKVCDGACYAYLPVHFAEEEAREFLELSEGRRKLVLDNVRRALCSALYYNPNDEDFECECGNSNTSWKRVCEDCGQVYAYSEMNLLQELSRIAATLSCNINELKNFTIHDIADEVSYAERSRRMTTVESGFKTVDEISLRTEVVGAVISEKPVEPVTVKAVVAEKPVEASNNSRVAMEEKQPQIKQVWRMVTEKPKPTVVPECKLEAPTKKEIQTCLDLVVQIGDFIINTCTREFKMVDGKSERIEKVEETEVKESVVENSNKDTVVLDNFFKNFQFNEERRSKIYTDKHGNVRYGRRPVKRQKRSKKVELMSDKIITKIEIPEEVQPVYSFEDLPSIKKAYSKEKPREIIETRTKYSVKSLVKEIGKTCSLTEIMIIDKKVRKIKRRGSRYFVDVRHLDGCNPEVDLDHSRFSDEILDWLMASLAVKSTRLSEIVPGTSGLITAGRNEFGKFTIIRGWLDRMVDAREKLTKSQLRRIRNYTIHGLHAFKKRYQTNVIDRERTTQIQIKDNVVYLKGEGALQNFINSSTLGGLVRNVSGATKPALACLRKATKYGVGFDMMMNHYVCCRCHVRCTDISLMDPMCSECGENMFESVGHESPFVTLPINPFECDVHPAVAEIMKEAWWRDGVEDWPIEKKYHSNGKEIYVEKQGQRAWRSEFQLRETSSNREFDLGLAAANNGVCLCEANFAWLDMFPCVTLNHIFGLDFDDDMDSEIRDIMTRENAQRVFSTGRLVKYADICPGWSGVVITEDAVQPEEWNKFAWYNGICVVQGKNRESGIIENAIIMKTADEKDKIDFYSFDLSWAKSKTKFIEYFAEDETRIIKACCTPSSLWLFAKKSSLYKYVDYLLLHESSIVDLCVKFEFVGKHLSLLENVEDACIEFSHFMDEMIQSRNVQDEPELARIRALIRSQFDSVRESSKYEIIDRIIEKKTKLQADEIIMRELIRRQYAELFSWRERALMNFCSKRTRLYDLWEKREEANSSSSSIISLLMSRPGLEIMTNWASTVCKTQYARSIRAVDCTIRFVWHRIVSLSKQALFKWWESCVFHVFCVLLTALVTYSLSQVVSFLKKMTDKEKKEALELEGDLVEIQGKKEEATIMKWCAMLTLVMSFINFDWALASVSALGKMKTIFSALGPNLIELQSGEEDAFKFTTFEVEVPGNGKSCDEQTFEDWISHCIKYNLTTPEPTTSGPMLVLEKGKAKELAEKIRMHDSCDLRVYGGVGTGKSTSLPSEIMKFGPVLICVPTRVLANALHDSYMALFGYDVSVAYRGRVRTGTQPITVMTYGYALNHFHYNPQNLNSFEYVVMDEIHTFPTELNPLFSLIRETNPRKKIIKTSATHVGHNVELSTNFKVNIETLSPMGVKKWVELQGTNVFGDATSSGEVILVFVATYNEVDEAAEGLRNKGFPVLKVDGRNFRKNTEVQKMVDDLPGTIKFIVATNIIENGVTLDVDTLVDFGERVSPVLDSDGRSIIMARRRISKAERQQRFGRVGRMKPGTIYKFGKEALPDSMKSVVGATESAMICFAYGIKPVVDDVDIGSIARVTKKQALTASLYDLNRIFTVHHVDKHGFIPRTVHELFKTFMLRTEAVAICESYLSSDSSSWKALHTYLRPSEEMAHVRNVKIPWYCSDMSNEFIIKLAECVNHAKPKFSCGYDVENVDFHVVAHKISVGEHNIEESKALVSEILNRVKQWRDNLVYKMSTPRNNSLMSLMVGWIPKKIEKTRSXLEMRIQRLEMLLSQLDNVSVNHDYESLVRFFAENPHSAEYLESQGKSEYLEKRILKTNIKEADWRVIAGVITITTCMAGFTYWYLRRRSAVDQVEIQGKVGYRRDKRVGRFVFDGPDEDIIENFGVEYSHDVVTKKMSKAQKLKQAKERGWKIGKVDRPKKIFKQLYGVNPLEFDEVYLTVGDFKGEIWETKDMDIDEMYSDLYSDFNLGNRKGYSKDVYLVFSKKDSDIEAVVDLQPHRSKMASSMSLNPMGFPEEEGRWRQSGDVKMRKRIEEEVEVQVAETAIASKFAHIFQRLGRLGFSGRGLNCIFHGDKSIMPYHLASGGDPGDSLIVTTSRGQFDMGPMEMIKCKKITDFDLVVGQLPKDMQPFKSTNIMRKPKMDEDVVIITLKRDKGKMLIRTSDTSKIYKAGDKYAHLWVHFIKSESGDCGSPIVALSDNKIVGFHSGMIKDKLGVFLRSVFTPVNDELLRTLNEKSEMNDFWKFNQDAISWNAVIKTSSLFPVMKDILGVHLQVGAGDKYIGGNLMTVGEVNKHAYHNHVIKGKRKEFVEFCAQNPNNNFEKFRDFYGPSVMTVSAFYKDLLKYDEPIRVGVIDFPSLVHAYLNVEDKLLSLGFDEDCGPEWDPYEIYCDLNKKAAMGALYQGSKNEWLKEITPKEFIEQVQESYRLLGHGVVGIWSGSLKAELRTKAKIAEGKTRVFTGAPIDVLLAGKVLVDKFNKHFYTQHLKGPWSVGINKFNRGWDKLARYFNHDWKFIDCDGSRFDSSLSPILFQMVCHMRERFGHFDWAETNALRNLYAQIVYTPILTIDGNIVKKHKGNNSGQPSTVVDNTLILMLVVEYCKSWHLKQSGIEMEFKYMCNGDDLIINAPDKEISIIQSTFKNLFKECGLNYDFDDLHDSIEDVEYMSHHFVLREGFYIPKLSKERLVAILEWERSDELFRTRSALNAAYIESFGYDDIHWEIERFAAYWANLKGVKNVLMSEDHVRKLYLDENFELTDEIVQTLSPASFEFGCVELQADEIDKEAIEQEIEKLRNEWKANGPSRTVSNYEARKKQTPIAAKVDELLKQLKEAGVETLKRPCGQPNADEDKKESSNSNWTGESEDEDEEKKKKMPLRGGGKILKRDDVDKIPTNAMEFKRDFKPARASRTSYIWIPRSQRDNLTPDVIKNFLAYIPPSQAIDNQMASGSQVENWAMRTASAYGVTIQQFYETVLPAWIVNCIVNGTSDERKTETVWRAVELNAQGEDVDDMEYPIEPIYKHALPTMRKIMRNFSSQAILMYQNSVAEGKAFTVKAARNAGYTEIEDQWLGIDFLAEAQLSRNQLNIKHQTLAANVSRNRRNLFALAAPGDDGRVNAERHLTTDASASRHTYGGAMIE",
"proteome": null,
"gene": null,
"go_terms": [
{
"identifier": "GO:0004197",
"name": "cysteine-type endopeptidase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0006508",
"name": "proteolysis",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0003676",
"name": "nucleic acid binding",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0005524",
"name": "ATP binding",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0008234",
"name": "cysteine-type peptidase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0003968",
"name": "RNA-directed RNA polymerase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0039694",
"name": "viral RNA genome replication",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0005198",
"name": "structural molecule activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0016818",
"name": "hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0018144",
"name": "RNA-protein covalent cross-linking",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0003723",
"name": "RNA binding",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0006351",
"name": "DNA-templated transcription",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0019028",
"name": "viral capsid",
"category": {
"code": "C",
"name": "cellular_component"
}
}
],
"protein_evidence": 4,
"source_database": "unreviewed",
"is_fragment": false,
"in_alphafold": false,
"in_bfvd": false,
"ida_accession": "63643b91120c0648a4e95401a373150e9ea6f685",
"counters": {
"domain_architectures": 6,
"entries": 38,
"isoforms": 0,
"proteomes": 0,
"sets": 4,
"structures": 0,
"taxa": 1,
"dbEntries": {
"profile": 5,
"smart": 2,
"pfam": 8,
"ssf": 3,
"cathgene3d": 3,
"cdd": 1,
"panther": 1,
"prints": 1,
"interpro": 14
},
"proteome": 0,
"taxonomy": 1,
"similar_proteins": 6
}
}
}
