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{
    "metadata": {
        "accession": "G2RGD6",
        "id": "G2RGD6_THETT",
        "source_organism": {
            "taxId": "578455",
            "scientificName": "Thermothielavioides terrestris (strain ATCC 38088 / NRRL 8126)",
            "fullName": "Thermothielavioides terrestris (strain ATCC 38088 / NRRL 8126)"
        },
        "name": "Double-strand break repair protein",
        "description": [
            "Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination"
        ],
        "length": 732,
        "sequence": "MPPAPEADTIRILVSTDNHVGFEERDPIRKDDSWRTFDEIMQLARTRDVDMVLLGGDLFHDNKPSRKAMYQVMRSLRKNCLGMKPCELEFLSDAAEVFEGAFPHVNYQDPDINISIPVFSIHGNHDDPSGDGHFCSLDLLQVAGLVNYFGRVSEADNIHVKPILLQKGKTKLALYGLSNVRDERMHRTFRDNKVRFYRPNQQKADFFNLLVLHQNHYAHTPTSYLPENMLPDFLDLVIWGHEHECLIDPQRNPETGFHVMQPGSSVATSLVPGEAATKHVAVLKITGKTFEVEKIPLKTVRPFVTREIVLANDKRFKGLEKKQDNRQDITKRLMLIVEEMIEEANAAWQSIHGGDDELDIDEQQPLPLIRLKVEYTAPDGAKFEVENPQRFSNRFAGKVANQNDVVYFYRKKTGTARKTKDMKALPAGVAENLGSMDTIKVDTLVQEFFAQQSLKILPQAQFGDAVNQFVSKDDKHAIEMFVMDSLSAQVKGLLQLDSDKITEGLDSHIEEFRKVMEQNFISGQQKQAQRKRRFKERPEHWDSDLDGHWTAQADAIEEVPGSPDPAISRPGRARPTSGVASNDEDGELFGEEPAAGAAAPRRTATAATGTSKRAASAQKTAAPARKAAAPKKAPARGRRKVNPFHDSDDEEEEEDVIMEDDDAEPEPPARAPPPKPTRETRARGPAKTRQTTLNFSQSQKPKAAQNAIEISDDEISDDDAFESMPQTRSRRR",
        "proteome": "UP000008181",
        "gene": "THITE_2122946",
        "go_terms": [
            {
                "identifier": "GO:0016787",
                "name": "hydrolase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0004519",
                "name": "endonuclease activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0030145",
                "name": "manganese ion binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006302",
                "name": "double-strand break repair",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0005634",
                "name": "nucleus",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            },
            {
                "identifier": "GO:0004520",
                "name": "DNA endonuclease activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0008296",
                "name": "3'-5'-DNA exonuclease activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0030870",
                "name": "Mre11 complex",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "425b0131cdd214c6ecbf46d49a3e42c2b170e652",
        "counters": {
            "domain_architectures": 4472,
            "entries": 16,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 2,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 2,
                "pfam": 2,
                "ssf": 1,
                "cdd": 1,
                "smart": 1,
                "pirsf": 1,
                "panther": 1,
                "ncbifam": 1,
                "interpro": 6
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 4472
        }
    }
}