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{
    "metadata": {
        "accession": "G1LUU4",
        "id": "G1LUU4_AILME",
        "source_organism": {
            "taxId": "9646",
            "scientificName": "Ailuropoda melanoleuca",
            "fullName": "Ailuropoda melanoleuca (Giant panda)"
        },
        "name": "RAS guanyl-releasing protein 4",
        "description": [
            "Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting Ras-mediated activation of PIK3CG/PI3Kgamma to promote neutrophil functional responses. In CD117(+) dendritic cells and mast cells, participates in an lipopolysaccharide (LPS)-activated signaling pathway that stimulates the production of interferon-gamma and other pro-inflammatory cytokines by natural killer (NK) cells. May function in mast cell differentiation. Does not appear to be required for the development of B-cells, DC-cells, T-cells, or NK-cells"
        ],
        "length": 673,
        "sequence": "MNRKDSKRKSHQECPGKTGGRGRPRQARRHKTCPSPREISKVMASMALGMLNEGGCSEDELLEKCIQSFDSAGSLRHGDHILNMVLAMHSWVLPSAHLAARLLTLYQEATGNTQEQRRLQICHLVRYWLTQHPETVHQEPQLEEVIGRFWATVEQEGNSAQRSLGDSSNLLSPGGPGPPPPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRGYVLQGSVRGCPALEGSVGLSNSVSRWVQVMVLSRPGPAQRAQVLDKFIQVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKALLELSELLAAHNNYARYRRTWADCTGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELAALQRQHPPCGASEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFKAPLVVEWAPGVTPKPDRATLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPHQGNGSYSREELTGYLLRASAICSKLGLAFLHNFQEVTFRKPTFCDSCSGFLWGVTKQGYRCRDCGLCCHKHCRDRVKVECKKRPGAKGDMSPPGAPVPPTLVPHASCGSEDNLSYTLSLEPETGCHLCHAWTQTEPPHPSWEPEMVPLPTTASPPAQSSKLNS",
        "proteome": "UP000008912",
        "gene": "RASGRP4",
        "go_terms": [
            {
                "identifier": "GO:0005085",
                "name": "guanyl-nucleotide exchange factor activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0007264",
                "name": "small GTPase-mediated signal transduction",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0005509",
                "name": "calcium ion binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "303b1c473b1040b5e9cf088ff2879651fe29d6f1",
        "counters": {
            "domain_architectures": 1476,
            "entries": 29,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 4,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 4,
                "profile": 4,
                "ssf": 2,
                "cdd": 3,
                "smart": 2,
                "pfam": 2,
                "panther": 1,
                "prints": 1,
                "prosite": 1,
                "interpro": 9
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 1476
        }
    }
}