General Handler

HTTP 200 OK
Allow: GET, HEAD
Content-Type: application/json
InterPro-Version: 108.0
InterPro-Version-Minor: 0
Vary: Accept

{
    "metadata": {
        "accession": "G1L781",
        "id": "G1L781_AILME",
        "source_organism": {
            "taxId": "9646",
            "scientificName": "Ailuropoda melanoleuca",
            "fullName": "Ailuropoda melanoleuca (Giant panda)"
        },
        "name": "Activating signal cointegrator 1",
        "description": [
            "Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription. May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a role in thyroid hormone receptor and estrogen receptor transactivation. Also involved in androgen receptor transactivation. Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B. May play a role in the development of neuromuscular junction. May play a role in late myogenic differentiation. Also functions as part of the RQC trigger (RQT) complex that activates the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation"
        ],
        "length": 581,
        "sequence": "MAVAGAASREQLVGWCTQQLRKTFGLDVSEEIMQYVLSIESAEEIREYVTDLLQGNEDKKGQFIEELIMKWQKNDQELSSDALQQSFKKDEMLDGQRSGDQLKRSRRKGRNRQEVPAFAEPDTTREVKTPFDLAKAQENSNSLKKKTKFVSLYTKEGQDRLAVLIPGRHPCDCLGQKHKLINNCLICGRIVCEQEGSGPCFFCGTLVCTREEQDILQRDSNKSQKLLKKLMSGTENSGKADISTKDLLPHQELRIKSGLEKAIKHKDKLLEFDRTSIRRTQVIDDESDYFASDSNQWLSKIERETLQKREEELREFRHMSRLSKKITIDFAGRKIVEDENPLAEYHSKLDETIQAIANGTLNQPLTKLDRSSDEPLGVLVNPNLYQSPPQWIDQTGAASQKKAFRSAGSELEFNSYRHQLRIQDQEFQEGFDGGWCLSMHQPWASLLVRGIKRVEGRSWYTPHRGRLWIAATAKRPSPQEVSELQTTYRVLRGKDVEFPNDYPSGCLLGCVDLIDCLSQKEFKDQYPDMSQESDSPFVFICTNPQEMIVKFPIKGNPKIWKLDSKIHQGAKKGLMKQNKAV",
        "proteome": "UP000008912",
        "gene": "TRIP4",
        "go_terms": [
            {
                "identifier": "GO:0008270",
                "name": "zinc ion binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0072344",
                "name": "rescue of stalled cytosolic ribosome",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0005634",
                "name": "nucleus",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            },
            {
                "identifier": "GO:0180022",
                "name": "RQC-trigger complex",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            }
        ],
        "protein_evidence": 4,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "978ebd5b7de0ff1cc5e194c9c293b90550b4897f",
        "counters": {
            "domain_architectures": 1265,
            "entries": 15,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 2,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "pfam": 4,
                "ssf": 1,
                "cdd": 1,
                "cathgene3d": 1,
                "smart": 1,
                "panther": 1,
                "interpro": 6
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 1265
        }
    }
}